A marked decrease in malaria-related deaths worldwide has been attributed to the
administration of effective antimalarials against Plasmodium falciparum, in particular …

New antimalarial targets are the prime need for the discovery of potent drug candidates. In
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …

Atg7 Deficiency Intensifies Inflammasome Activation and Pyroptosis in Pseudomonas Sepsis |
The Journal of Immunology | American Association of Immunologists Skip to Main Content …

Artemisinin resistance threatens worldwide malaria control and elimination. Elevation of
phosphatidylinositol-3-phosphate (PI3P) can induce resistance in blood stages of …

Artemisinin-based combination therapies (ACTs) have substantially reduced worldwide
malaria burden and deaths. But malaria parasites have become resistant to artemisinins …

The Rrf2 family transcription factor NsrR controls expression of genes in a wide range of
bacteria in response to nitric oxide (NO). The precise form of the NO-sensing module of …

Autophagy is a lysosomal degradation pathway of eukaryotic cells that is highly conserved
from yeast to mammals. During this process, cooperating protein complexes are recruited in …

Plasmodium falciparum exports proteins into erythrocytes using the Plasmodium export
element (PEXEL) motif, which is cleaved in the endoplasmic reticulum (ER) by plasmepsin V …

Autophagy is an evolutionarily conserved process that degrades and recycles defective
organelles, toxic proteins, and various other aggregates on the cytoplasmic surface by …

Autophagy is a catabolic process widely conserved among eukaryotes that permits the rapid
degradation of unwanted proteins and organelles through the lysosomal pathway. This …