C. elegans in high-throughput drug discovery

LP O'Reilly, CJ Luke, DH Perlmutter… - Advanced drug delivery …, 2014 - Elsevier
Caenorhabditis elegans has been proven to be a useful model organism for investigating
molecular and cellular aspects of numerous human diseases. More recently, investigators …

[HTML][HTML] Where are all the anthelmintics? Challenges and opportunities on the path to new anthelmintics

SA Nixon, C Welz, DJ Woods, L Costa-Junior… - International Journal for …, 2020 - Elsevier
Control of helminth parasites is a key challenge for human and veterinary medicine. In the
absence of effective vaccines and adequate sanitation, prophylaxis and treatment commonly …

EzColocalization: An ImageJ plugin for visualizing and measuring colocalization in cells and organisms

W Stauffer, H Sheng, HN Lim - Scientific reports, 2018 - nature.com
Insight into the function and regulation of biological molecules can often be obtained by
determining which cell structures and other molecules they localize with (ie. colocalization) …

Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure

J Ma, A Guillot, Z Yang, B Mackowiak… - The Journal of …, 2022 - Am Soc Clin Investig
Intrahepatic neutrophil infiltration has been implicated in severe alcoholic hepatitis (SAH)
pathogenesis; however, the mechanism underlying neutrophil-induced injury in SAH …

Classifying and segmenting microscopy images with deep multiple instance learning

OZ Kraus, JL Ba, BJ Frey - Bioinformatics, 2016 - academic.oup.com
Motivation: High-content screening (HCS) technologies have enabled large scale imaging
experiments for studying cell biology and for drug screening. These systems produce …

VATA: a poly (vinyl alcohol)-and tannic acid-based nontoxic underwater adhesive

D Lee, H Hwang, JS Kim, J Park, D Youn… - … applied materials & …, 2020 - ACS Publications
Few studies aiming to develop a glue with an underwater reusable adhesive property have
been reported because combining the two properties of reusable adhesion and underwater …

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

G Günes Günsel, TM Conlon, A Jeridi, R Kim… - Nature …, 2022 - nature.com
Extravasation of monocytes into tissue and to the site of injury is a fundamental
immunological process, which requires rapid responses via post translational modifications …

Transcriptome analysis of adult Caenorhabditis elegans cells reveals tissue-specific gene and isoform expression

R Kaletsky, V Yao, A Williams, AM Runnels… - PLoS …, 2018 - journals.plos.org
The biology and behavior of adults differ substantially from those of develo** animals, and
cell-specific information is critical for deciphering the biology of multicellular animals. Thus …

[HTML][HTML] Using Machine Learning to make nanomaterials sustainable

JJ Scott-Fordsmand, MJB Amorim - Science of The Total Environment, 2023 - Elsevier
Sustainable development is a key challenge for contemporary human societies; failure to
achieve sustainability could threaten human survival. In this review article, we illustrate how …

Maternal age generates phenotypic variation in Caenorhabditis elegans

MF Perez, M Francesconi, C Hidalgo-Carcedo… - Nature, 2017 - nature.com
Genetically identical individuals that grow in the same environment often show substantial
phenotypic variation within populations of organisms as diverse as bacteria, nematodes …