Skeletal muscle is a tissue with a low mitochondrial content under basal conditions, but it is
responsive to acute increases in contractile activity patterns (ie exercise) which initiate the …

Several molecular mechanisms are involved in the regulation of skeletal muscle function.
Among them, mitochondrial activity can be identified. The mitochondria is an important and …

Aging skeletal muscles are characterized by a progressive decline in muscle mass and
muscular strength. Such muscular dysfunctions are usually associated with structural and …

Myosteatosis is the pathologic accumulation of lipid that can occur in conjunction with
atrophy and fibrosis following skeletal muscle injury. Little is known about the mechanisms …

Sarcopenia is the loss of both muscle mass and function with age. Although the molecular
underpinnings of sarcopenia are not fully understood, numerous pathways are implicated …

Background Although thermoregulation is effective in regulating body temperature under
normal conditions, exercise or physical activity in extreme cold or heat exerts heavy stress …

Deficits in skeletal muscle mitochondrial content and quality are observed following
denervation‐atrophy. This is due to alterations in the biogenesis of new mitochondria as well …

Lysosomes play a critical role as a terminal organelle in autophagy flux and in regulating
protein degradation, but their function and adaptability in skeletal muscle is understudied …

Inactivity and ageing can have a detrimental impact on skeletal muscle and the
neuromuscular junction (NMJ). Decreased physical activity results in muscle atrophy …

Key points Traumatic nerve injury or nerve disease leads to denervation and severe muscle
atrophy. Recent evidence shows that mitochondrial loss could be a key mediator of skeletal …