Studies of retroviruses have led to many extraordinary discoveries that have advanced our
understanding of not only human diseases, but also molecular biology as a whole. The most …

For HIV virions to become infectious, the immature lattice of Gag polyproteins attached to the
virion membrane must be cleaved. Cleavage cannot initiate without the protease formed by …

Cryogenic electron tomography (cryoET) is capable of determining in situ biological
structures of molecular complexes at near-atomic resolution by averaging half a million …

One of the striking features of human immunodeficiency virus (HIV) is the capsid, a fullerene
cone comprised of pleomorphic capsid protein (CA) that shields the viral genome and …

Cryogenic electron tomography (cryoET) is capable of determining in situ biological
structures of molecular complexes at near atomic resolution by averaging half a million …

HIV is a lentivirus characterized by the formation of its mature core. Visualization and
structural examination of HIV requires purification of virions to high concentrations. The yield …