A large family of chromatin remodelers that noncovalently modify chromatin is crucial in cell
development and differentiation. They are often the targets of cancer, neurological disorders …

Nucleosomes, the basic organizational units of chromatin, package and regulate eukaryotic
genomes. ATP-dependent nucleosome-remodeling factors endow chromatin with structural …

The prokaryotic CRISPR (clustered regularly interspaced palindromic repeats)-associated
protein, Cas9, has been widely adopted as a tool for editing, imaging, and regulating …

Chromatin-remodelling complexes (CRCs) mobilize nucleosomes to mediate the access of
DNA-binding factors to their sites in vivo. These CRCs contain a catalytic subunit that bears …

Arrays of regularly spaced nucleosomes dominate chromatin and are often phased by
alignment to reference sites like active promoters. How the distances between nucleosomes …

ATP-dependent chromatin remodelling enzymes (remodellers) regulate DNA accessibility in
eukaryotic genomes. Many remodellers reposition (slide) nucleosomes, however, how DNA …

Chromatin remodelers use the energy of ATP hydrolysis to reposition or evict nucleosomes
or to replace canonical histones with histone variants. By regulating nucleosome dynamics …

Despite their canonical two-fold symmetry, nucleosomes in biological contexts are often
asymmetric: functionalized with post-translational modifications (PTMs), substituted with …

The acidic patch is a functionally important epitope on each face of the nucleosome that
affects chromatin remodeling. Although related by 2-fold symmetry of the nucleosome, each …

Arrays of regularly spaced nucleosomes are a hallmark of chromatin, but it remains unclear
how they are generated. Recent genome-wide studies, in vitro and in vivo, showed constant …