Metabolic reprogramming is a general feature of cancer cells. Regrettably, the
comprehensive quantification of metabolites in biological specimens does not promptly …

Laboratory models derived from clinical samples represent a solid platform in preclinical
research for drug testing and investigation of disease mechanisms. The integration of these …

Motivation Intratumour heterogeneity poses many challenges to the treatment of cancer.
Unfortunately, the transcriptional and metabolic information retrieved by currently available …

In this work it is shown that scale-free tails in metabolic flux distributions inferred in stationary
models are an artifact due to reactions involved in thermodynamically unfeasible cycles …

Modeling and Simulation (M&S) is one of the most multifaceted topics present today in both
industry and academia. However, we are involved in a new M&S paradigm. Systems are …

Motivation Metabolic reprogramming is a general feature of cancer cells. Regrettably, the
comprehensive quantification of metabolites in biological specimens does not promptly …