Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease

JY Lee, A Martin-Bastida, A Murueta-Goyena… - Nature Reviews …, 2022 - nature.com
Parkinson disease (PD) is a progressive disorder characterized by dopaminergic
neurodegeneration in the brain. The development of parkinsonism is preceded by a long …

Circadian regulation in aging: Implications for spaceflight and life on earth

D Malhan, B Schoenrock, M Yalçin, D Blottner… - Aging …, 2023 - Wiley Online Library
Alterations in the circadian system are characteristic of aging on Earth. With the decline in
physiological processes due to aging, several health concerns including vision loss …

Circadian and sleep dysfunctions in neurodegenerative disorders—An update

K Fifel, A Videnovic - Frontiers in Neuroscience, 2021 - frontiersin.org
Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in
patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered …

Degeneration of human photosensitive retinal ganglion cells may explain sleep and circadian rhythms disorders in Parkinson's disease

I Ortuño-Lizarán, G Esquiva, TG Beach… - Acta neuropathologica …, 2018 - Springer
Parkinson's disease (PD) patients often suffer from non-motor symptoms like sleep
dysregulation, mood disturbances or circadian rhythms dysfunction. The melanopsin …

The effects of bright light therapy on depression and sleep disturbances in patients with Parkinson's disease: a systematic review and meta-analysis of randomized …

F Lin, Y Su, Y Weng, X Lin, H Weng, G Cai, G Cai - Sleep Medicine, 2021 - Elsevier
Background Depression and sleep disturbance are well-recognized non-motor features in
patients with Parkinson's disease (PD). This meta-analysis aimed to explore the potential …

[HTML][HTML] Circadian alterations in patients with neurodegenerative diseases: Neuropathological basis of underlying network mechanisms

K Fifel, A Videnovic - Neurobiology of Disease, 2020 - Elsevier
Circadian organization of physiology and behavior is an important biological process that
allows organisms to anticipate and prepare for daily changes and demands. Disruptions in …

Chronotherapies for Parkinson's disease

K Fifel, A Videnovic - Progress in neurobiology, 2019 - Elsevier
Parkinson's disease (PD) is the second-most common progressive neurodegenerative
disorder. Although the clinical diagnosis of PD is still based on its cardinal motor …

Respiratory disorders of Parkinson's disease

YC Aquino, LM Cabral, NC Miranda… - Journal of …, 2021 - journals.physiology.org
Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra, mainly affecting people over 60 yr of age. Patients develop both …

A nanoparticle-based wireless deep brain stimulation system that reverses Parkinson's disease

J Wu, X Cui, L Bao, G Liu, X Wang, C Chen - Science Advances, 2025 - science.org
Deep brain stimulation technology enables the neural modulation with precise spatial
control but requires permanent implantation of conduits. Here, we describe a photothermal …

Exploring the key parameters for indoor light intervention in treating neurodegenerative diseases: A systematic review

K Su, C Wang, J **ang - Building and Environment, 2024 - Elsevier
Light, essential for health and well-being, has shown promise for treating neurodegenerative
diseases (NDDs). Indoor light intervention (ILI) has become a widely utilized approach in …