Endochondral ossification, the process by which most of the skeleton is formed, is a powerful
system for studying various aspects of the biological response to degraded extracellular …

The extracellular matrix (ECM) is a complex of self assembled macromolecules. It is
composed predominantly of collagens, non-collagenous glycoproteins, hyaluronan and …

Human mesenchymal stem cells (hMSC) represent a promising cell-based therapy for a
number of degenerative conditions. Understanding the effect of aging on hMSCs is crucial …

The established function of thyroid stimulating hormone (TSH) is to promote thyroid follicle
development and hormone secretion. The osteoporosis associated with hyperthyroidism is …

Objective Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS) induces pro-
inflammatory cytokines, such as interleukin-1 β (IL-1β), IL-6, and IL-8, which induce …

Paget disease of bone (PD) is characterized by excessive bone resorption in focal areas
followed by abundant new bone formation, with eventual replacement of the normal bone …

Osteogenesis is a complex process associated with dramatic changes in gene expression.
To elucidate whether modifications in chromatin structure are involved in osteoblast …

The treatment of oral and periodontal diseases and associated anomalies accounts for a
significant proportion of the healthcare burden, with the manifestations of these conditions …

In a previous paper, we pointed out that the capability to synthesize glycine from serine is
constrained by the stoichiometry of the glycine hydroxymethyltransferase reaction, which …

Osterix (Osx) is essential for osteoblast differentiation and bone formation, because mice
lacking Osx die within 1 h of birth with a complete absence of intramembranous and …