The American College of Rheumatology's case definitions for 19 neuropsychiatric
syndromes in systemic lupus erythematosus (SLE) constitute a comprehensive classification …

Cognitive dysfunction (CD) is a common yet often clinically subtle manifestation that
considerably impacts the health-related quality of life in patients with systemic lupus …

Objective Cortical spreading depolarizations (CSDs) are intense and ubiquitous
depolarization waves relevant for the pathophysiology of migraine and brain injury. CSDs …

Lipopolysaccaride (LPS) directly or indirectly injures brain microvascular endothelial cells
(BMECs) and damages the intercellular tight junction that gives rise to altered blood-brain …

N-Methyl-D-aspartate glutamate receptors (NMDARs) are involved in multiple
physiopathological processes, including synaptic plasticity, neuronal network activities …

We all know about classical fibrinolysis, how plasminogen activation by either tissue‐type
plasminogen activator (t‐PA) or urokinase‐type plasminogen activator (u‐PA) promotes …

Myocardial infarction and ischemic stroke are the most frequent causes of death or disability
worldwide. Due to their ability to dissolve blood clots, the thrombolytics are frequently used …

Increase in blood–brain barrier (BBB) permeability is a crucial step in neuroinflammatory
processes. We previously showed that N Methyl D Aspartate Receptor (NMDARs) …

The cerebral microcirculation holds a critical position to match the high metabolic demand
by neuronal activity. Functionally, microcirculation is virtually inseparable from other nervous …

Cerebral ischemia (stroke) induces injury to the cerebral endothelium that may contribute to
parenchymal injury and worsen outcome. This review focuses on current preclinical studies …