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The mitophagy pathway and its implications in human diseases
S Wang, H Long, L Hou, B Feng, Z Ma, Y Wu… - Signal transduction and …, 2023 - nature.com
Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …
death and programmed apoptotic, and are crucial for cell metabolism and survival …
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases
L Qian, Y Zhu, C Deng, Z Liang, J Chen… - Signal transduction and …, 2024 - nature.com
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s),
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …
[HTML][HTML] Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease
Parkinson's disease (PD) is mediated, in part, by intraneuronal accumulation of α-synuclein
aggregates andsubsequent death of dopamine (DA) neurons in the substantia nigra pars …
aggregates andsubsequent death of dopamine (DA) neurons in the substantia nigra pars …
CYLD in health and disease
ABSTRACT CYLD lysine 63 deubiquitinase (CYLD) is a ubiquitin hydrolase with important
roles in immunity and cancer. Complete CYLD ablation, truncation and expression of …
roles in immunity and cancer. Complete CYLD ablation, truncation and expression of …
Peroxisom proliferator-activated receptor-γ coactivator-1α in neurodegenerative disorders: A promising therapeutic target
YN Yang, MQ Zhang, FL Yu, B Han, MY Bao… - Biochemical …, 2023 - Elsevier
Neurodegenerative disorders (NDDs) are characterized by progressive loss of selectively
vulnerable neuronal populations and myelin sheath, leading to behavioral and cognitive …
vulnerable neuronal populations and myelin sheath, leading to behavioral and cognitive …
[HTML][HTML] Investigating the Interplay between Mitophagy and Diabetic Neuropathy: Uncovering the hidden secrets of the disease pathology
Mitophagy, the cellular process of selectively eliminating damaged mitochondria, plays a
crucial role in maintaining metabolic balance and preventing insulin resistance, both key …
crucial role in maintaining metabolic balance and preventing insulin resistance, both key …
The absence of parkin does not promote dopamine or mitochondrial dysfunction in PolgAD257A/D257A mitochondrial mutator mice
Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra pars compacta (SNpc). In this study, we generated a transgenic …
in the substantia nigra pars compacta (SNpc). In this study, we generated a transgenic …
[HTML][HTML] Bioactivated Glucoraphanin Modulates Genes Involved in Necroptosis on Motor-Neuron-like Nsc-34: A Transcriptomic Study
A Minuti, A Trainito, A Gugliandolo, I Anchesi… - Antioxidants, 2024 - mdpi.com
Research on bioactive compounds has grown recently due to their health benefits and
limited adverse effects, particularly in reducing the risk of chronic diseases, including …
limited adverse effects, particularly in reducing the risk of chronic diseases, including …
The potential of cylindromatosis (CYLD) as a therapeutic target in oxidative stress-associated pathologies: a comprehensive evaluation
Z Huang, Y Tan - International Journal of Molecular Sciences, 2023 - mdpi.com
Oxidative stress (OS) arises as a consequence of an imbalance between the formation of
reactive oxygen species (ROS) and the capacity of antioxidant defense mechanisms to …
reactive oxygen species (ROS) and the capacity of antioxidant defense mechanisms to …
Cell biology of Parkin: clues to the development of new therapeutics for Parkinson's disease
Parkinson's disease is the second most prevalent neurodegenerative disease and
contributes significantly to morbidity globally. Currently, no disease-modifying therapies exist …
contributes significantly to morbidity globally. Currently, no disease-modifying therapies exist …