The adaptive immune response to influenza virus infection is multifaceted and complex,
involving antibody and cellular responses at both systemic and mucosal levels. Immune …

Seasonal influenza viruses cause recurring global epidemics by continually evolving to
escape host immunity. The viral constraints and host immune responses that limit and drive …

The protective efficacy of serum antibodies results from the interplay of antigen-specific B
cell clones of different affinities and specificities. These cellular dynamics underlie serum …

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome–coronavirus 2 (SARS-CoV-2) has now become a pandemic, but there is currently …

We introduce the TRUST4 open-source algorithm for reconstruction of immune receptor
repertoires in αβ/γδ T cells and B cells from RNA-sequencing (RNA-seq) data. Compared …

Seasonal influenza viruses constantly change through antigenic drift and the emergence of
pandemic influenza viruses through antigenic shift is unpredictable. Conventional influenza …

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by
antinuclear antibodies (ANAs) that form immune complexes that mediate pathogenesis by …

Despite decades of surveillance and pharmaceutical and non-pharmaceutical interventions,
seasonal influenza viruses continue to cause epidemics around the world each year. The …

Antibodies to the hemagglutinin (HA) and neuraminidase (NA) glycoproteins are the major
mediators of protection against influenza virus infection. Here, we report that current …

Antigenic drift refers to the evolutionary accumulation of amino acid substitutions in viral
proteins selected by host adaptive immune systems as the virus circulates in a population …