Inhibiting fatty acid synthesis overcomes colistin resistance
Treating multidrug-resistant infections has increasingly relied on last-resort antibiotics,
including polymyxins, for example colistin. As polymyxins are given routinely, the prevalence …
including polymyxins, for example colistin. As polymyxins are given routinely, the prevalence …
A molecular overview of the polymyxin-LPS interaction in the context of its mode of action and resistance development
With the rising incidences of antimicrobial resistance (AMR) and the diminishing options of
novel antimicrobial agents, it is paramount to decipher the molecular mechanisms of action …
novel antimicrobial agents, it is paramount to decipher the molecular mechanisms of action …
Structural biology of MCR-1-mediated resistance to polymyxin antibiotics
IC Materon, T Palzkill - Current Opinion in Structural Biology, 2023 - Elsevier
Polymyxins, a last resort antibiotic, target the outer membrane of pathogens and are used to
address the increasing prevalence of multidrug-resistant Gram-negative bacteria. The …
address the increasing prevalence of multidrug-resistant Gram-negative bacteria. The …
Reaction‐Induced Self‐Assembly of Polymyxin Mitigates Cytotoxicity and Reverses Drug Resistance
Polymyxins have been regarded as an efficient therapeutic against many life‐threatening,
multidrug resistant Gram‐negative bacterial infections; however, the cytotoxicity and …
multidrug resistant Gram‐negative bacterial infections; however, the cytotoxicity and …
Interaction of designed cationic antimicrobial peptides with the outer membrane of gram-negative bacteria
S He, CM Deber - Scientific Reports, 2024 - nature.com
The outer membrane (OM) is a hallmark feature of gram-negative bacteria that provides the
species with heightened resistance against antibiotic threats while cationic antimicrobial …
species with heightened resistance against antibiotic threats while cationic antimicrobial …
Discovery of antibiotics that selectively kill metabolically dormant bacteria
There is a need to discover and develop non-toxic antibiotics that are effective against
metabolically dormant bacteria, which underlie chronic infections and promote antibiotic …
metabolically dormant bacteria, which underlie chronic infections and promote antibiotic …
Lateral membrane organization as target of an antimicrobial peptidomimetic compound
Antimicrobial resistance is one of the leading concerns in medical care. Here we study the
mechanism of action of an antimicrobial cationic tripeptide, AMC-109, by combining high …
mechanism of action of an antimicrobial cationic tripeptide, AMC-109, by combining high …
Lipopeptide antibiotics disrupt interactions of undecaprenyl phosphate with UptA
The peptidoglycan pathway represents one of the most successful antibacterial targets with
the last critical step being the flip** of carrier lipid, undecaprenyl phosphate (C55-P) …
the last critical step being the flip** of carrier lipid, undecaprenyl phosphate (C55-P) …
Functional Materials to Overcome Bacterial Barriers and Models to Advance Their Development
A Bali, MAM Kamal, G Mulla, B Loretz… - Advanced Functional …, 2023 - Wiley Online Library
With the emerging problem of antimicrobial resistance, the world is facing a slow but
dangerous pandemic. While the discovery of novel antibiotics is reaching a nearly …
dangerous pandemic. While the discovery of novel antibiotics is reaching a nearly …
Eradication of bacterial persister cells by leveraging their low metabolic activity using adenosine triphosphate coated gold nanoclusters
LA Bekale, D Sharma, B Bacacao, J Chen… - Nano Today, 2023 - Elsevier
Bacteria first develop tolerance after antibiotic exposure; later genetic resistance emerges
through the population of tolerant bacteria. Bacterial persister cells are the multidrug-tolerant …
through the population of tolerant bacteria. Bacterial persister cells are the multidrug-tolerant …