Liposomes and polymersomes: a comparative review towards cell mimicking

E Rideau, R Dimova, P Schwille, FR Wurm… - Chemical society …, 2018 - pubs.rsc.org
Cells are integral to all forms of life due to their compartmentalization by the plasma
membrane. However, living organisms are immensely complex. Thus there is a need for …

Recent advances of cell membrane‐coated nanomaterials for biomedical applications

WL Liu, MZ Zou, SY Qin, YJ Cheng… - Advanced Functional …, 2020 - Wiley Online Library
Surface modification of nanomaterials is essential for their biomedical applications owing to
their passive immune clearance and damage to reticuloendothelial systems. Recently, a cell …

Polymer nano-systems for the encapsulation and delivery of active biomacromolecular therapeutic agents

M Machtakova, H Thérien-Aubin… - Chemical society …, 2022 - pubs.rsc.org
Biomacromolecular therapeutic agents, particularly proteins, antigens, enzymes, and nucleic
acids are emerging as powerful candidates for the treatment of various diseases and the …

Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier

S Nyberg, NJ Abbott, X Shi, PS Steyger… - Science translational …, 2019 - science.org
Permanent hearing loss affects more than 5% of the world's population, yet there are no
nondevice therapies that can protect or restore hearing. Delivery of therapeutics to the …

Permeable protein-loaded polymersome cascade nanoreactors by polymerization-induced self-assembly

LD Blackman, S Varlas, MC Arno, A Fayter… - ACS macro …, 2017 - ACS Publications
Enzyme loading of polymersomes requires permeability to enable them to interact with the
external environment, typically requiring addition of complex functionality to enable porosity …

Confinement of therapeutic enzymes in selectively permeable polymer vesicles by polymerization-induced self-assembly (PISA) reduces antibody binding and …

LD Blackman, S Varlas, MC Arno, ZH Houston… - ACS central …, 2018 - ACS Publications
Covalent PEGylation of biologics has been widely employed to reduce immunogenicity,
while improving stability and half-life in vivo. This approach requires covalent protein …

Overcoming the incompatibility challenge in chemoenzymatic and multi‐catalytic cascade reactions

S Schmidt, K Castiglione… - Chemistry–A European …, 2018 - Wiley Online Library
Multi‐catalytic cascade reactions bear a great potential to minimize downstream and
purification steps, leading to a drastic reduction of the produced waste. In many examples …

Building reconfigurable devices using complex liquid–fluid interfaces

J Forth, PY Kim, G **e, X Liu, BA Helms… - Advanced …, 2019 - Wiley Online Library
Liquid–fluid interfaces provide a platform both for structuring liquids into complex shapes
and assembling dimensionally confined, functional nanomaterials. Historically, attention in …

Dynamic metastable polymersomes enable continuous flow manufacturing

CK Wong, RY Lai, MH Stenzel - Nature Communications, 2023 - nature.com
Polymersomes are polymeric analogues of liposomes with exceptional physical and
chemical properties. Despite being dubbed as next-generation vesicles since their inception …

Overcoming the dilemma of permeability and stability of polymersomes through traceless cross-linking

X Wang, J Hu, S Liu - Accounts of Chemical Research, 2022 - ACS Publications
Conspectus In nature, cells are highly compartmentalized into many organelles that are well
separated from the rest of the cellular space by unique membrane structures, which are of …