Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the
most abundant sterol in mammals, is a key component of cell membranes although it does …

Cholesterol is dynamically transported among organelles, which is essential for multiple
cellular functions. However, the mechanism underlying intracellular cholesterol transport …

Steroid hormones are made from cholesterol, primarily derived from lipoproteins that enter
cells via receptor-mediated endocytosis. In endo-lysosomes, cholesterol is released from …

The physiological importance of cholesterol in the cell plasma membrane has attracted
increased attention in recent years. Consequently, the use of methods of controlled …

Cholesterol plays an indispensable role in regulating the properties of cell membranes in
mammalian cells. Recent advances suggest that cholesterol exerts many of its actions …

Basal cell carcinoma, medulloblastoma, rhabdomyosarcoma and other human tumours are
associated with mutations that activate the proto-oncogene Smoothened (SMO) or that …

Background This is an update of a Cochrane review first published in 2001. At that stage
there was insufficient evidence to recommend statins for the prevention of Alzheimer's …

Abstract Simian virus 40 (SV40) is unusual among animal viruses in that it enters cells
through caveolae, and the internalized virus accumulates in a smooth endoplasmic …

Animal cells control their membrane lipid composition within narrow limits, but the sensing
mechanisms underlying this control are largely unknown. Recent studies disclosed a protein …