Vascular endothelial cells form the inner layer of blood vessels where they have a key role
in the development and maintenance of the functional circulatory system and provide …

Ischemic stroke is one of the significant causes of morbidity and mortality, affecting millions
of people across the globe. Cell injury in the infarct region is an inevitable consequence of …

The widespread availability of programmable site-specific nucleases now enables targeted
gene disruption in the zebrafish. In this study, we applied site-specific nucleases to generate …

Abstract Development of the retinal vasculature is based on highly coordinated signalling
between different cell types of the retina, integrating internal metabolic requirements with …

Hematopoietic stem cells (HSCs) underlie the production of blood and immune cells for the
lifetime of an organism. In vertebrate embryos, HSCs arise from the unique …

Notch signaling, a highly conserved pathway in mammals, is crucial for differentiation and
homeostasis of immune cells. Besides, this pathway is also directly involved in the …

Although it is well accepted that the Notch signaling pathway is essential for vascular
morphogenesis, its contributions to the homeostasis of adult endothelium were uncovered …

Our vasculature plays diverse and critical roles in homeostasis and disease. In recent
decades, the use of zebrafish has driven our understanding of vascular development into …

The formation of a hierarchical vascular network, composed of arteries, veins, and
capillaries, is essential for embryogenesis and is required for the production of new …

Vascular endothelial growth factor a (Vegfa) is essential for blood vessel formation and can
induce activation of numerous signaling effectors in endothelial cells. However, it is unclear …