Metastatic disease is the principal cause of prostate-cancer-related mortality. Our ability to
accurately recapitulate the spread of prostate cancer to bone—the most common site of …

Liver cancer is one of the most common malignant tumors worldwide, it is ranked sixth in
incidence and fourth in mortality. According to the distinct origin of malignant tumor cells …

HOXB13 is a key lineage homeobox transcription factor that plays a critical role in the
differentiation of the prostate gland. Several studies have suggested that HOXB13 …

Abstract The Cancer Genome Atlas (TCGA) has accrued RNA-Seq-based transcriptome
data for more than 4000 cancer tissue samples across 12 cancer types, translating these …

Objectives SPARCL1 is a matricellular protein that mediates the cell–matrix interactions and
participates in physiological processes such as cell adhesion, differentiation and …

Different tumor microenvironments (TMEs) induce stromal cell plasticity that affects
tumorigenesis. The impact of TME-dependent heterogeneity of tumor endothelial cells …

Tumor progression to metastasis is not cancer cell autonomous, but rather involves the
interplay of multiple cell types within the tumor microenvironment. Here we identify asporin …

Abstract The Rb-E2F axis is an important pathway involved in cell-cycle control that is
deregulated in a number of cancers. E2f transcription factors have distinct roles in the control …

NME1 is a well-documented metastasis suppressor gene, with suppressor activity
demonstrated across a wide spectrum of human cancers including melanoma and …

The aim of this study was to clarify the significance of DNA methylation alterations during
lung carcinogenesis. Infinium assay was performed using 139 paired samples of non …