Many biologically active small‐molecule natural products produced by microorganisms
derive their activities from sugar substituents. Changing the structures of these sugars can …

Glycosylation of small molecules like specialized (secondary) metabolites has a profound
impact on their solubility, stability or bioactivity, making glycosides attractive compounds as …

A large number of antibiotics are glycosides. In numerous cases the glycosidic residues are
crucial to their activity; sometimes, glycosylation only improves their pharmacokinetic …

Mammalian cell surfaces are all covered with bioactive oligosaccharides which play an
important role in molecular recognition events such as immune recognition, cell–cell …

Forosamine (4-dimethylamino)-2, 3, 4, 6-tetradeoxy-β-d-threo-hexopyranose) is a highly
deoxygenated sugar component of several important natural products, including the potent …

Lincomycin A is a potent antimicrobial agent noted for its unusual C1 methylmercapto-
substituted 8-carbon sugar. Despite its long clinical history for the treatment of Gram-positive …

Polyene antibiotics such as nystatin are a large family of very valuable antifungal polyketide
compounds typically produced by soil actinomycetes. Previously, using a polyene …

PLP is well-regarded for its role as a coenzyme in a number of diverse enzymatic reactions.
Transamination, deoxygenation, and aldol reactions mediated by PLP-dependent enzymes …

Lincomycin A is a clinically useful antibiotic isolated from Streptomyces lincolnensis. It
contains an unusual methylmercapto-substituted octose, methylthiolincosamide (MTL) …

Many biologically active bacterial natural products contain highly modified deoxysugar
residues that are often critical for the activity of the parent compounds. Most of these …