Decoding the spermatogenesis program: new insights from transcriptomic analyses
Spermatogenesis is a complex differentiation process coordinated spatiotemporally across
and along seminiferous tubules. Cellular heterogeneity has made it challenging to obtain …
and along seminiferous tubules. Cellular heterogeneity has made it challenging to obtain …
Spermatogonial stem cells: updates from specification to clinical relevance
Human spermatogonia are target for exploration of adult stem cell characteristics and
potential source for the development of therapeutic applications. Almost 50 years ago, Yves …
potential source for the development of therapeutic applications. Almost 50 years ago, Yves …
[HTML][HTML] The mammalian spermatogenesis single-cell transcriptome, from spermatogonial stem cells to spermatids
Spermatogenesis is a complex and dynamic cellular differentiation process critical to male
reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene …
reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene …
Spatiotemporal developmental trajectories in the Arabidopsis root revealed using high-throughput single-cell RNA sequencing
High-throughput single-cell RNA sequencing (scRNA-seq) is becoming a cornerstone of
developmental research, providing unprecedented power in understanding dynamic …
developmental research, providing unprecedented power in understanding dynamic …
High-throughput single nucleus total RNA sequencing of formalin-fixed paraffin-embedded tissues by snRandom-seq
Z Xu, T Zhang, H Chen, Y Zhu, Y Lv, S Zhang… - Nature …, 2023 - nature.com
Formalin-fixed paraffin-embedded (FFPE) tissues constitute a vast and valuable patient
material bank for clinical history and follow-up data. It is still challenging to achieve single …
material bank for clinical history and follow-up data. It is still challenging to achieve single …
The molecular evolution of spermatogenesis across mammals
The testis produces gametes through spermatogenesis and evolves rapidly at both the
morphological and molecular level in mammals,,,,–, probably owing to the evolutionary …
morphological and molecular level in mammals,,,,–, probably owing to the evolutionary …
The mouse microbiome is required for sex-specific diurnal rhythms of gene expression and metabolism
The circadian clock and associated feeding rhythms have a profound impact on metabolism
and the gut microbiome. To what extent microbiota reciprocally affect daily rhythms of …
and the gut microbiome. To what extent microbiota reciprocally affect daily rhythms of …
Male gametes are generated through a specialised differentiation pathway involving a
series of developmental transitions that are poorly characterised at the molecular level …
series of developmental transitions that are poorly characterised at the molecular level …
[HTML][HTML] Optimizing nervous system-specific gene targeting with Cre driver lines: prevalence of germline recombination and influencing factors
The Cre-loxP system is invaluable for spatial and temporal control of gene knockout,
knockin, and reporter expression in the mouse nervous system. However, we report varying …
knockin, and reporter expression in the mouse nervous system. However, we report varying …
Testis single-cell RNA-seq reveals the dynamics of de novo gene transcription and germline mutational bias in Drosophila
The testis is a peculiar tissue in many respects. It shows patterns of rapid gene evolution and
provides a hotspot for the origination of genetic novelties such as de novo genes …
provides a hotspot for the origination of genetic novelties such as de novo genes …