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Pathogenesis of acquired heterotopic ossification: risk factors, cellular mechanisms, and therapeutic implications
G Cao, S Zhang, Y Wang, S Quan, C Yue, J Yao… - Bone, 2023 - Elsevier
Heterotopic ossification (HO), including hereditary and acquired HO, is the formation of
extraskeletal bone in skeletal muscle and surrounding soft tissues. Acquired HO is often …
extraskeletal bone in skeletal muscle and surrounding soft tissues. Acquired HO is often …
Neurological heterotopic ossification: current understanding and future directions
Neurological heterotopic ossification (NHO) involves the formation of bone in soft tissue
following a neurological condition, of which the most common are brain and spinal cord …
following a neurological condition, of which the most common are brain and spinal cord …
Neurological heterotopic ossification: novel mechanisms, prognostic biomarkers and prophylactic therapies
Neurological heterotopic ossification (NHO) is a debilitating condition where bone forms in
soft tissue, such as muscle surrounding the hip and knee, following an injury to the brain or …
soft tissue, such as muscle surrounding the hip and knee, following an injury to the brain or …
[HTML][HTML] Relationship between heterotopic ossification and traumatic brain injury: why severe traumatic brain injury increases the risk of heterotopic ossification
Heterotopic ossification (HO) is a pathological phenomenon in which ectopic lamellar bone
forms in soft tissues. HO involves many predisposing factors, including congenital and …
forms in soft tissues. HO involves many predisposing factors, including congenital and …
Post‐traumatic heterotopic ossification: an old problem in need of new solutions
Heterotopic ossification (HO) is the formation of pathological bone in ectopic sites and it can
have serious consequences for functional outcomes. For many years, its main clinical …
have serious consequences for functional outcomes. For many years, its main clinical …
Bone replaces articular cartilage in the rat knee joint after prolonged immobilization
Background Lost joint range of motion (ROM) is common in chronic osteoarthritis, alters
regional weight-bearing across the articular surfaces, and contributes to loss of cartilage and …
regional weight-bearing across the articular surfaces, and contributes to loss of cartilage and …
[HTML][HTML] The effect of traumatic brain injury on bone healing from a novel exosome centered perspective in a mice model
C Yang, C Gao, N Liu, Y Zhu, X Zhu, X Su… - Journal of orthopaedic …, 2021 - Elsevier
Background In patients with traumatic brain injury (TBI) combined with long bone fracture,
the fracture healing is always faster than that of patients with single fracture, which is …
the fracture healing is always faster than that of patients with single fracture, which is …
Macrophage-derived neurotrophin-3 promotes heterotopic ossification in rats
J Zhang, L Wang, J Chu, X Ao, T Jiang, B Yan… - Laboratory …, 2020 - nature.com
Heterotopic ossification (HO) is a debilitating condition that results from traumatic injuries or
genetic diseases, for which the underlying mechanisms remain unclear. Recently, we have …
genetic diseases, for which the underlying mechanisms remain unclear. Recently, we have …
Enpp1 mutations promote upregulation of hedgehog signaling in heterotopic ossification with aging
Z He, Z Zhu, T Tang, F Wang, P Guo, J Li… - Journal of Bone and …, 2024 - Springer
Introduction Heterotopic ossification of the tendon and ligament (HOTL) is a chronic
progressive disease that is usually accompanied by thickening and ossification of ligaments …
progressive disease that is usually accompanied by thickening and ossification of ligaments …
Occurrence and predictive factors of heterotopic ossification in severe acquired brain injured patients during rehabilitation stay: cross-sectional survey
Objectives: To report occurrence and identify patient's features and risk factors of heterotopic
ossifications in patients with severe acquired brain injury in intensive rehabilitation centres …
ossifications in patients with severe acquired brain injury in intensive rehabilitation centres …