Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators

JL Brodsky, G Chiosis - Current Topics in Medicinal Chemistry, 2006 - benthamdirect.com
Molecular chaperones are best known for their ability to aid in the solubilization of mis-
folded proteins, and as a result play essential roles in protein folding, degradation, and …

Oncogenic transformation by BK virus and association with human tumors

M Tognon, A Corallini, F Martini, M Negrini… - Oncogene, 2003 - nature.com
BK virus (BKV), a human polyomavirus closely related to JC virus and Simian Virus 40, is
ubiquitous in human populations worldwide. After primary infection, BKV establishes a …

Seroepidemiology of the human polyomaviruses

A Stolt, K Sasnauskas, P Koskela… - Journal of General …, 2003 - microbiologyresearch.org
To assess the stability of polyomavirus antibodies in serial samples over time and the
incidence and age-specific prevalence of polyomavirus infections, we established enzyme …

Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity

SW Fewell, CM Smith, MA Lyon, TP Dumitrescu… - Journal of Biological …, 2004 - jbc.org
The molecular chaperone and cytoprotective activities of the Hsp70 and Hsp40 chaperones
represent therapeutic targets for human diseases such as cancer and those that arise from …

BK virus and human cancer: innocent until proven guilty

JR Abend, M Jiang, MJ Imperiale - Seminars in cancer biology, 2009 - Elsevier
BK virus (BKV) is a polyomavirus that ubiquitously infects the human population. Following a
typically subclinical primary infection, BKV establishes a life-long persistent infection in the …

Detection of human polyomaviruses and papillomaviruses in prostatic tissue reveals the prostate as a habitat for multiple viral infections

A Zambrano, M Kalantari, A Simoneau… - The …, 2002 - Wiley Online Library
BACKGROUND To determine whether human polyomavirus (hPy) genomes are present in
prostate tissues, we have carried out a polymerase chain reaction (PCR) screening in two …

BK virus in solid organ transplant recipients: an emerging syndrome

E Mylonakis, N Goes, RH Rubin, AB Cosimi… - …, 2001 - journals.lww.com
BK virus is a human polyomavirus associated with a range of clinical presentations from
asymptomatic viruria with pyuria to ureteral ulceration with ureteral stenosis in renal …

Bladder carcinoma in a transplant recipient: evidence to implicate the BK human polyomavirus as a causal transforming agent

D Geetha, BC Tong, L Racusen, JS Markowitz… - …, 2002 - journals.lww.com
The BK polyomavirus (BKV) infects most of the human population, but clinically relevant
infections are mostly limited to individuals who are immunosuppressed. In transplant …

The human polyomaviruses, BKV and JCV: molecular pathogenesis of acute disease and potential role in cancer

MJ Imperiale - Virology, 2000 - Elsevier
The two human polyomaviruses, BKV and JCV, have lived much of their lives in the
shadows of their more intensively studied simian and murine cousins, SV40 and Py. JCV …

[HTML][HTML] Simian virus 40 infection in humans and association with human diseases: results and hypotheses

G Barbanti-Brodano, S Sabbioni, F Martini, M Negrini… - Virology, 2004 - Elsevier
Simian virus 40 (SV40) is a monkey virus that was introduced in the human population by
contaminated poliovaccines, produced in SV40-infected monkey cells, between 1955 and …