Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Voltage‐gated calcium channels are essential players in many physiological processes in
excitable cells. There are three main subdivisions of calcium channel, defined by the pore …

Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …

The gabapentinoids, gabapentin, and pregabalin, target the α2δ subunits of voltage-gated
calcium channels. Initially licensed for pain and seizures, they have become widely …

Childhood absence epilepsy is an idiopathic, generalized non-convulsive epilepsy with a
multifactorial genetic aetiology. Molecular-genetic analyses of affected human families and …

Neuropathic pain results from damage to the peripheral sensory nervous system, which may
have a number of causes. The calcium channel subunit α2δ-1 is upregulated in dorsal root …

Voltage-gated calcium channels are important mediators of several physiological processes,
including neuronal excitability and muscle contraction. At the molecular level, the channels …

Voltage-gated calcium channels consist of the main pore-forming α1 subunit, together,
except in the case of the T-type channels, with β and α2δ and sometimes γ subunits, which …

Abstract Episodic ataxia type-2 (EA2) is caused by mutations in P/Q-type voltage-gated
calcium channels that are expressed at high densities in cerebellar Purkinje cells. Because …

In this review, we examine what is known about the mechanism of action of the auxiliary α 2
δ subunits of voltage-gated Ca 2+(Ca v) channels. First, to provide some background on the …