Gram-negative bacteria characteristically are surrounded by an additional membrane layer,
the outer membrane. Although outer membrane components often play important roles in …

Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …

Integral membrane proteins come in two types, α-helical and β-barrel proteins. In both types,
all hydrogen bonding donors and acceptors of the polypeptide backbone are completely …

The human cathelicidin LL-37 serves a critical role in the innate immune system defending
bacterial infections. LL-37 can interact with molecules of the cell wall and perforate …

In nanometer-sized apertures with charged surfaces, the extension of the electrical double
layer results in the electrostatic exclusion of co-ions and enrichment in counterions, which …

Gram negative bacteria have evolved many mechanisms of attaching to and invading host
epithelial and immune cells. In particular, many outer membrane proteins (OMPs) are …

Beta-barrel membrane proteins occur in the outer membranes of Gram-negative bacteria,
mitochondria and chloroplasts. The membrane-spanning sequences of β-barrel membrane …

The amino acid composition and architecture of all β‐barrel membrane proteins of known
three‐dimensional structure have been examined to generate information that will be useful …

This work describes the development of a program that predicts whether or not a
polypeptide sequence from a Gram-negative bacterium is an integral β-barrel outer …

PenB is the third resistance determinant in the stepwise acquisition of multiple resistance
genes in chromosomally mediated resistant Neisseria gonorrhoeae (CMRNG). Alterations in …