The protein-folding chaperone Hsp90 has been proposed to buffer the phenotypic effects of
mutations. The potential for Hsp90 and other putative buffers to increase robustness to …

Pleiotropy—when a single mutation affects multiple traits—is a controversial topic with far-
reaching implications. Pleiotropy plays a central role in debates about how complex traits …

Morphological phenoty** of the budding yeast Saccharomyces cerevisiae has helped to
greatly clarify the functions of genes and increase our understanding of cellular functional …

The demand for phenomics, a high-dimensional and high-throughput phenoty** method,
has been increasing in many fields of biology. The budding yeast Saccharomyces …

The budding yeast Saccharomyces cerevisiae has been used as a model organism for the
basic mechanism of aging, which provides useful assay systems for measuring both …

Modification of the genetic background and, in some cases, the introduction of targeted
mutations can play a critical role in producing trait characteristics during the breeding of …

Single-cell analysis has become one of the main cornerstones of biotechnology, inspiring
the advent of various microfluidic compartments for cell cultivation such as microwells …

Although evolution by natural selection is widely regarded as the most important principle of
biology, it is unknown whether phenotypic variations within and between species are mostly …

Haploinsufficiency, a dominant phenotype caused by a heterozygous loss-of-function
mutation, has been rarely observed. However, high-dimensional single-cell phenoty** of …

Morphological profiling is an omics-based approach for predicting intracellular targets of
chemical compounds in which the dose-dependent morphological changes induced by the …