Dysregulation of transcriptional condensates in human disease: mechanisms, biological functions, and open questions

KM Mathias, Y Liu, L Wan - Current Opinion in Genetics & Development, 2024 - Elsevier
Highlights•Transcriptional components can form dense assemblies termed condensates.•
Transcriptional condensates arise from interactions among proteins, RNA, or …

Biomolecular condensates in immune cell fate

S Kodali, CM Sands, L Guo, Y Huang… - Nature Reviews …, 2025 - nature.com
Fate decisions during immune cell development require temporally precise changes in gene
expression. Evidence suggests that the dynamic modulation of these changes is associated …

Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape

L Song, Q Li, L **a, AE Sahay, Q Qiu, Y Li, H Li… - Nature …, 2024 - nature.com
How disruptions to normal cell differentiation link to tumorigenesis remains incompletely
understood. Wilms tumor, an embryonal tumor associated with disrupted organogenesis …

[HTML][HTML] The Pivotal Role of LACTB in the Process of Cancer Development

M Zhang, B Wu, J Gu - International Journal of Molecular Sciences, 2025 - mdpi.com
The mitochondrial serine β-lactamase-like protein LACTB has emerged as a critical
regulator in cancer biology, distinguished by its unique structural and functional attributes …

ENL mutation and AML: a new model that reveals oncogenic condensate's function in leukemogenesis

Z Fan, Y Jiang, X Zhang - Molecular oncology, 2025 - Wiley Online Library
Precise regulation of gene expression is essential for proper development and the
maintenance of homeostasis in organisms. Studies have shown that some transcriptional …