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Dysregulation of transcriptional condensates in human disease: mechanisms, biological functions, and open questions
Highlights•Transcriptional components can form dense assemblies termed condensates.•
Transcriptional condensates arise from interactions among proteins, RNA, or …
Transcriptional condensates arise from interactions among proteins, RNA, or …
Biomolecular condensates in immune cell fate
S Kodali, CM Sands, L Guo, Y Huang… - Nature Reviews …, 2025 - nature.com
Fate decisions during immune cell development require temporally precise changes in gene
expression. Evidence suggests that the dynamic modulation of these changes is associated …
expression. Evidence suggests that the dynamic modulation of these changes is associated …
Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape
How disruptions to normal cell differentiation link to tumorigenesis remains incompletely
understood. Wilms tumor, an embryonal tumor associated with disrupted organogenesis …
understood. Wilms tumor, an embryonal tumor associated with disrupted organogenesis …
[HTML][HTML] The Pivotal Role of LACTB in the Process of Cancer Development
M Zhang, B Wu, J Gu - International Journal of Molecular Sciences, 2025 - mdpi.com
The mitochondrial serine β-lactamase-like protein LACTB has emerged as a critical
regulator in cancer biology, distinguished by its unique structural and functional attributes …
regulator in cancer biology, distinguished by its unique structural and functional attributes …
ENL mutation and AML: a new model that reveals oncogenic condensate's function in leukemogenesis
Z Fan, Y Jiang, X Zhang - Molecular oncology, 2025 - Wiley Online Library
Precise regulation of gene expression is essential for proper development and the
maintenance of homeostasis in organisms. Studies have shown that some transcriptional …
maintenance of homeostasis in organisms. Studies have shown that some transcriptional …