The immune system is essential for maintaining homeostasis, as well as promoting growth
and healing throughout the brain and body. Considering that immune cells respond rapidly …

Background The use of nanomaterials is constantly increasing in electronics, cosmetics,
food additives, and is emerging in advanced biomedical applications such as theranostics …

Explosive blast-induced mild traumatic brain injury (mTBI), a “signature wound” of recent
military conflicts, commonly affects service members. While past blast injury studies have …

Background Amyotrophic lateral sclerosis (ALS) is a clinically and histopathologically
heterogeneous neurodegenerative disorder, in which therapy is hindered by the rapid …

Large scale unbiased quantification of immunohistochemistry (IHC) is time consuming,
expensive, and/or limited in scope. Heterogeneous tissue types such as brain tissue have …

AAV-mediated optogenetic neural stimulation has become a clinical approach for restoring
function in sensory disorders and feasibility for hearing restoration has been indicated in …

Traumatic brain injury (TBI) remains a significant clinical problem and contributes to one-
third of all injury-related deaths. Activated microglia-mediated inflammatory response is a …

Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide.
Detailed studies of the microglial response after TBI require high throughput quantification of …

Whole Slide Images (WSIs) in digital pathology are used to diagnose cancer subtypes. The
difference in procedures to acquire WSIs at various trial sites gives rise to variability in the …

Traumatic brain injury (TBI) is a disabling neurotraumatic condition and the leading cause of
injury-related deaths and disability in the United States. Attenuation of neuroinflammation …