An intricate molecular machinery is at the core of gene expression regulation in every cell.
During the initial stages of organismal development, the coordinated activation of diverse …

Nearly 7 decades have elapsed since Francis Crick introduced the central dogma of
molecular biology, as part of his ideas on protein synthesis, setting the fundamental rules of …

Homotypic chromatin interactions and loop extrusion are thought to be the two main drivers
of mammalian chromosome folding. Here we tested the role of RNA polymerase II (RNAPII) …

Abstract The Encyclopedia of DNA Elements (ENCODE) project has established a genomic
resource for mammalian development, profiling a diverse panel of mouse tissues at 8 …

Bivalent chromatin is characterized by the simultaneous presence of H3K4me3 and
H3K27me3, histone modifications generally associated with transcriptionally active and …

Abstract The three-dimensional (3D) structure of chromatin is intrinsically associated with
gene regulation and cell function,–. Methods based on chromatin conformation capture have …

Technology for measuring 3D genome topology is increasingly important for studying gene
regulation, for genome assembly and for map** of genome rearrangements. Hi-C and …

It is essential for cells to control which genes are transcribed into RNA. In eukaryotes, two
major control points are recruitment of RNA polymerase II (Pol II) into a paused state, and …

R-loops are three-stranded nucleic acid structures that form during transcription, especially
over unmethylated CpG-rich promoters of active genes. In mouse embryonic stem cells …

The functional maturation of neurons is a prolonged process that extends past the mitotic
exit and is mediated by the chromatin-dependent orchestration of gene transcription …