Over the past few decades, a significant number of anticancer drugs have been developed,
both natural and synthetic. Thiazole, a 5-membered distinctive heterocyclic motif with …

Sulfonamides have gained prominence as versatile agents in cancer therapy, effectively
targeting a spectrum of cancer-associated enzymes. This review provides an extensive …

A series of new indole-oxadiazole derivatives was designed and synthesized to develop
potential anti-breast cancer agents. The compounds exhibited significant inhibitory activity …

In vitro 3D cancer spheroids (tumoroids) exhibit a drug resistance profile similar to that found
in solid tumors. 3D spheroid culture methods recreate more physiologically relevant …

Simple Summary Endocrine therapy is a common treatment for estrogen-responsive breast
cancer, which is used to block the tumor growth-promoting effect of this hormone. The …

Xanthine Oxidase inhibitors treat hyperuricemia, but associated side effects have led
researchers to discover new inhibitors with fewer side effects. Our study employed a hybrid …

Hyperuricemia, a disease characterized by elevation of serum uric acid level beyond 6
mg/dL. This elevation led to appearance of symptoms from joint pain to gout and from gout to …

Based on the structural architecture of estrogen receptors (ER) agonists/antagonists, we
rationally designed and synthesized indenopyrimidine-2, 5-dione analogs as a starting point …

Breast cancer is a major threat to women's lives throughout the world. Hormone-dependent
or estrogen-receptor positive (ER+) breast cancer accounts for more than 80% of all …

Background: Soothing the liver (called Shu Gan Jie Yu in Chinese, SGJY) is a significant
therapeutic method for breast cancer in TCM. In this study, 3 liver-soothing herbs, including …