Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

Abstract Coronavirus disease 2019 (COVID-19)-associated invasive fungal infections are an
important complication in a substantial number of critically ill, hospitalized patients with …

The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …

Inflammasomes are important sentinels of innate immune defence, sensing pathogens and
inducing cell death in infected cells. There are several inflammasome sensors that each …

The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …

The innate immune system initiates cell death pathways in response to pathogens and
cellular stress. Cell death can be either non-lytic (apoptosis) or lytic (PANoptosis, pyroptosis …

PANoptosis, a new research hotspot at the moment, is a cell death pattern in which
pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence …

Cell death provides host defense and maintains homeostasis. Zα-containing molecules are
essential for these processes. Z-DNA binding protein 1 (ZBP1) activates inflammatory cell …

Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …