Magic-angle spinning (MAS) nuclear magnetic resonance (NMR) is establishing itself as a
powerful method for the characterization of protein dynamics at the atomic scale. We discuss …

We present near-atomic-resolution cryo-EM structures of the mammalian voltage-gated
potassium channel Kv1. 2 in open, C-type inactivated, toxin-blocked and sodium-bound …

NMR spectroscopy presents boundless opportunities for understanding the structure,
dynamics, and function for a broad range of scientific applications. Solid-state NMR …

Evolution from precellular supramolecular assemblies to cellular world originated from the
ability to make a barrier between the interior of the cell and the outer environment. This step …

K+ channel activity can be limited by C-type inactivation, which is likely initiated in part by
dissociation of K+ ions from the selectivity filter and modulated by the side chains that …

We identified a new human voltage-gated potassium channel blocker, NnK-1, in the jellyfish
Nemopilema nomurai based on its genomic information. The gene sequence encoding NnK …

Potassium channels are essential for regulating cellular excitability by controlling K+ ion
flow. In voltage-gated potassium (Kv) channels, C-type inactivation modulates action …

The bacterial ion channel KcsA has become a useful model of complex K+-ion channels
thanks to its single pore domain structure whose sequence shares many similarities with …

Biomolecular solid-state nuclear magnetic resonance (NMR) 1 spectroscopy has developed
into an important player in integrated structural biology. 2 Compared to NMR in solution, this …

Proteins are a major constituent of cellular membranes, with an average plasma membrane
being approximately 50% membrane proteins by mass. 1 In addition to their large number …