Among the neurotransmitters involved in addiction, dopamine (DA) is clearly the best known.
The critical role of DA in addiction is supported by converging evidence that has been …

Dopamine (DA) plays a well recognized role in a variety of physiologic functions such as
movement, cognition, mood, and reward. Consequently, many human disorders are due, in …

Abstract Na+/Cl–-coupled biogenic amine transporters are the primary targets of therapeutic
and abused drugs, ranging from antidepressants to the psychostimulants cocaine and …

The precise regulation of synaptic dopamine (DA) content by the DA transporter (DAT)
ensures the phasic nature of the DA signal, which underlies the ability of DA to encode …

Solute carrier family 6 member 1 (SLC6A1) is abundantly expressed in the develo** brain
even before the CNS is formed. Its encoded GABA transporter 1 (GAT-1) is responsible for …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by altered social
interaction and communication, and repetitive, restricted, inflexible behaviors. Approximately …

Dopamine was first identified as a neurotransmitter localized to the midbrain over 50 years
ago. The dopamine transporter (DAT; SLC 6A3) and the vesicular monoamine transporter 2 …

Germline de novo missense variants of the CACNA1D gene, encoding the pore-forming α1
subunit of Cav1. 3 L-type Ca 2+ channels (LTCCs), have been found in patients with …

Increasing extracellular levels of serotonin (5-HT) in the brain ameliorates symptoms of
depression and anxiety-related disorders, eg, social phobias and post-traumatic stress …

Neurotransmitters, such as γ-aminobutyric acid, glutamate, acetyl choline, glycine and the
monoamines, facilitate the crosstalk within the central nervous system. The designated …