Human cytomegalovirus (HCMV), a betaherpesvirus, represents the major infectious cause
of birth defects, as well as an important pathogen for immunocompromised individuals. The …

Classical microbiology techniques are relatively slow in comparison to other analytical
techniques, in many cases due to the need to culture the microorganisms. Furthermore …

Viral replication requires energy and macromolecular precursors derived from the metabolic
network of the host cell. Despite this reliance, the effect of viral infection on host cell …

Mechanistic insights to viral replication and pathogenesis generally have come from the
analysis of viral gene products, either by studying their biochemical activities and …

Proliferation of mammalian cells can be controlled by low cultivation temperature. However,
depending on cell type and expression system, varying effects of a temperature shift on …

To replicate their genomes in cells and generate new progeny, viruses typically require
factors provided by the cells that they have infected. Subversion of the cellular machinery …

We used differential display analysis to identify mRNAs that accumulate to enhanced levels
in human cytomegalovirus-infected cells as compared with mock-infected cells. RNAs were …

The effect of human cytomegalovirus (HCMV) infection on cellular mRNA accumulation was
analyzed by gene chip technology. During a 48-h time course after infection of human …

The nuclear lamina is a major obstacle encountered by herpesvirus nucleocapsids in their
passage from the nucleus to the cytoplasm (nuclear egress). We found that the human …

Human cytomegalovirus (HCMV) infection inhibits cell cycle progression and alters the
expression of cyclins E, A, and B (FM Jault, J.-M. Jault, F. Ruchti, EA Fortunato, C. Clark, J …