Intracellular signals of T cell costimulation
Ligation of T cell receptor (TCR) alone is insufficient to induce full activation of T
lymphocytes. Additional ligand-receptor interactions (costimulation) on antigen presenting …
lymphocytes. Additional ligand-receptor interactions (costimulation) on antigen presenting …
Trispecific antibody targeting HIV-1 and T cells activates and eliminates latently-infected cells in HIV/SHIV infections
W Promsote, L Xu, J Hataye, G Fabozzi… - Nature …, 2023 - nature.com
Agents that can simultaneously activate latent HIV, increase immune activation and enhance
the killing of latently-infected cells represent promising approaches for HIV cure. Here, we …
the killing of latently-infected cells represent promising approaches for HIV cure. Here, we …
A highly potent anti-VISTA antibody KVA12123-a new immune checkpoint inhibitor and a promising therapy against poorly immunogenic tumors
S Iadonato, Y Ovechkina, K Lustig, J Cross… - Frontiers in …, 2023 - frontiersin.org
Background Immune checkpoint therapies have led to significant breakthroughs in cancer
patient treatment in recent years. However, their efficiency is variable, and resistance to …
patient treatment in recent years. However, their efficiency is variable, and resistance to …
Upregulation of IL-9 and JAK-STAT signaling pathway in children with autism
Autism spectrum disorder (ASD) gradually develops predominantly neurodevelopmental
disorders, which are socially diagnosed in early childhood. Though the etiopathology of …
disorders, which are socially diagnosed in early childhood. Though the etiopathology of …
Upregulation of FcγRIIb on monocytes is necessary to promote the superagonist activity of TGN1412
K Hussain, CE Hargreaves… - Blood, The Journal …, 2015 - ashpublications.org
The anti-CD28 superagonist antibody TGN1412 caused life-threatening cytokine release
syndrome (CRS) in healthy volunteers, which had not been predicted by preclinical testing …
syndrome (CRS) in healthy volunteers, which had not been predicted by preclinical testing …
Monitoring cytokine profiles during immunotherapy
JC Siebert, EB Walker - Immunotherapy, 2010 - Taylor & Francis
Measuring cytokine production is an integral part of measuring immune response during
immunotherapy. Current technologies allow the simultaneous quantification of multiple …
immunotherapy. Current technologies allow the simultaneous quantification of multiple …
Single CD28 stimulation induces stable and polyclonal expansion of human regulatory T cells
Abstract CD4+ FOXP3+ Treg are essential for immune tolerance. Phase-1 clinical trials of
Treg-therapy to treat graft-versus-host-disease reported safety and potential therapeutic …
Treg-therapy to treat graft-versus-host-disease reported safety and potential therapeutic …
A novel form of 4-1BBL has better immunomodulatory activity than an agonistic anti-4-1BB Ab without Ab-associated severe toxicity
RH Schabowsky, KG Elpek, S Madireddi, RK Sharma… - Vaccine, 2009 - Elsevier
Agonistic Abs to select costimulatory members of CD28 and TNFR family have shown
efficacy in various preclinical cancer immunotherapeutic settings. However, the use of …
efficacy in various preclinical cancer immunotherapeutic settings. However, the use of …
The effect of extracorporeal photopheresis alone or in combination therapy on circulating CD4+Foxp3+CD25− T cells in patients with leukemic cutaneous T‐cell …
LH Shiue, J Couturier, DE Lewis, C Wei… - Photodermatology …, 2015 - Wiley Online Library
Purpose Extracorporeal photopheresis (ECP) alone or in combination therapy is effective for
treatment of leukemic cutaneous T‐cell lymphoma (L‐CTCL), but its mechanism (s) of action …
treatment of leukemic cutaneous T‐cell lymphoma (L‐CTCL), but its mechanism (s) of action …
Development of a flow cytometry-based potency assay for prediction of cytokine storms induced by biosimilar monoclonal antibodies
Cytokine release syndrome (CRS) is an undesired immune reaction that may cause
dangerous side effects after the administration of novel biological therapies. In vitro cytokine …
dangerous side effects after the administration of novel biological therapies. In vitro cytokine …