Highlights•The most common reason for the failure of the cancer treatment is the evolving
drug resistance.•The ABC transporters mainly P-gp, BCRP and MRP1 are responsible for …

Traditional Chinese medicine (TCM) has been practiced for thousands of years and at the
present time is widely accepted as an alternative treatment for cancer. In this review, we …

Multidrug resistance (MDR) is the dominant cause of the failure of cancer chemotherapy.
The design of antitumor drugs that are able to evade MDR is rapidly evolving, showing that …

As a result of metabolic reprogramming, cancer cells display high rates of glycolysis,
causing an excess production of lactate along with an increase in extracellular acidity …

Phytochemicals have long been effective partners in the fight against several diseases,
including cancer. Among these, flavonoids are valuable allies for both cancer prevention …

Cost-efficacy of currently applied treatments is an issue in overall cancer management
challenging healthcare and causing tremendous economic burden to societies around the …

Multidrug-resistance (MDR) featuring complicated and poorly defined mechanisms is a
major obstacle to the success of cancer chemotherapy in the clinic. Compound …

Dealing with cancer is of importance due to enhanced incidence rate of this life-threatening
disorder. Chemotherapy is an ideal candidate in overcoming and eradication of cancer. To …

Multidrug resistance (MDR), defined as the ability of cancer cells to gain resistance to both
conventional and novel chemotherapy agents, is an important barrier in treating …

Docetaxel is the first-line chemotherapy agent for metastatic prostate cancer. However, the
emergence of resistance diminishes its efficacy and limits the survival benefit. Quercetin is a …