On modeling

DS Novikov, VG Kiselev… - Magnetic resonance in …, 2018 - Wiley Online Library
Map** tissue microstructure with MRI holds great promise as a noninvasive window into
tissue organization at the cellular level. Having originated within the realm of diffusion NMR …

Quantifying brain microstructure with diffusion MRI: Theory and parameter estimation

DS Novikov, E Fieremans, SN Jespersen… - NMR in …, 2019 - Wiley Online Library
We review, systematize and discuss models of diffusion in neuronal tissue, by putting them
into an overarching physical context of coarse‐graining over an increasing diffusion length …

[HTML][HTML] SANDI: a compartment-based model for non-invasive apparent soma and neurite imaging by diffusion MRI

M Palombo, A Ianus, M Guerreri, D Nunes… - Neuroimage, 2020 - Elsevier
This work introduces a compartment-based model for apparent cell body (namely soma) and
neurite density imaging (SANDI) using non-invasive diffusion-weighted MRI (DW-MRI). The …

Noninvasive quantification of axon radii using diffusion MRI

J Veraart, D Nunes, U Rudrapatna, E Fieremans… - elife, 2020 - elifesciences.org
Axon caliber plays a crucial role in determining conduction velocity and, consequently, in the
timing and synchronization of neural activation. Noninvasive measurement of axon radii …

[HTML][HTML] Neurite Exchange Imaging (NEXI): A minimal model of diffusion in gray matter with inter-compartment water exchange

IO Jelescu, A de Skowronski, F Geffroy, M Palombo… - NeuroImage, 2022 - Elsevier
Biophysical models of diffusion in white matter have been center-stage over the past two
decades and are essentially based on what is now commonly referred to as the “Standard …

[HTML][HTML] Challenges for biophysical modeling of microstructure

IO Jelescu, M Palombo, F Bagnato… - Journal of Neuroscience …, 2020 - Elsevier
The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25
years. In this review, we dwell on the various challenges along the journey of bringing a …

Rotationally-invariant map** of scalar and orientational metrics of neuronal microstructure with diffusion MRI

DS Novikov, J Veraart, IO Jelescu, E Fieremans - NeuroImage, 2018 - Elsevier
We develop a general analytical and numerical framework for estimating intra-and extra-
neurite water fractions and diffusion coefficients, as well as neurite orientational dispersion …

[HTML][HTML] Diffusion time dependence, power-law scaling, and exchange in gray matter

JL Olesen, L Østergaard, N Shemesh, SN Jespersen - NeuroImage, 2022 - Elsevier
Characterizing neural tissue microstructure is a critical goal for future neuroimaging.
Diffusion MRI (dMRI) provides contrasts that reflect diffusing spins' interactions with myriad …

[HTML][HTML] Post mortem map** of connectional anatomy for the validation of diffusion MRI

A Yendiki, M Aggarwal, M Axer, AFD Howard… - NeuroImage, 2022 - Elsevier
Diffusion MRI (dMRI) is a unique tool for the study of brain circuitry, as it allows us to image
both the macroscopic trajectories and the microstructural properties of axon bundles in vivo …

Towards unconstrained compartment modeling in white matter using diffusion‐relaxation MRI with tensor‐valued diffusion encoding

B Lampinen, F Szczepankiewicz… - Magnetic resonance …, 2020 - Wiley Online Library
Purpose To optimize diffusion‐relaxation MRI with tensor‐valued diffusion encoding for
precise estimation of compartment‐specific fractions, diffusivities, and T2 values within a two …