Insulin is a peptide secreted by the pancreas and plays an important role in the regulation of
glucose metabolism in peripheral tissues. Although the role of insulin in the periphery is well …

Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …

Insulin signalling in the central nervous system regulates energy homeostasis by controlling
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …

Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …

Alzheimer's disease (AD) is the most common form of dementia in the elderly followed by
vascular dementia. In addition to clinically diagnosed dementia, cognitive dysfunction has …

Insulin acts on the CNS to modulate behaviour and systemic metabolism. Disturbances in
brain insulin action represent a possible link between metabolic and cognitive health …

Metabolic syndrome (MetS), which is characterized by insulin resistance, high blood
glucose, obesity, and dyslipidemia, is known to increase the risk of dementia accompanied …

There is growing evidence that patients with Type 2 diabetes have an increased risk of
develo** Parkinson's disease and share similar dysregulated pathways suggesting …

Brain insulin signaling contributes to memory function and might be a viable target in the
prevention and treatment of memory impairments including Alzheimer's disease. This short …

Over the past few years, evidence has accumulated that the human brain is an insulin-
sensitive organ. Insulin regulates activity in a limited number of specific brain areas that are …