The global prevalence of diabetes mellitus and Alzheimer's disease is increasing alarmingly
with the aging of the population. Numerous epidemiological data suggest that there is a …

Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

In the last decade, much attention has been devoted to the effects of nutrient-related signals
on brain development and cognitive functions. A turning point was the discovery that brain …

Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous
systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to …

Insulin receptors, as well as IGF-1 receptors and their postreceptor signaling partners, are
distributed throughout the brain. Insulin acts on these receptors to modulate peripheral …

N-methyl-d-aspartate receptors (NMDARs) are located in neuronal cell membranes at
synaptic and extrasynaptic locations, where they are believed to mediate distinct …

The synapse is a crucial element in biological neural networks, but a simple electronic
equivalent has been absent. This complicates the development of hardware that imitates …

Impairment of working memory is one of the most important deleterious effects of marijuana
intoxication in humans, but its underlying mechanisms are presently unknown. Here, we …

Though discovered over 100 years ago, the molecular foundation of sporadic Alzheimer's
disease (AD) remains elusive. To better characterize the complex nature of AD, we …

Synaptic plasticity serves as a cellular substrate for information storage in the central
nervous system. The entorhinal cortex (EC) and hippocampus are interconnected brain …