Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids
RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …
Walking a tightrope: the complex balancing act of R-loops in genome stability
JR Brickner, JL Garzon, KA Cimprich - Molecular cell, 2022 - cell.com
Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
Intertwining roles of R-loops and G-quadruplexes in DNA repair, transcription and genome organization
R-loops are three-stranded nucleic acid structures that are abundant and widespread across
the genome and that have important physiological roles in many nuclear processes. Their …
the genome and that have important physiological roles in many nuclear processes. Their …
[HTML][HTML] ROS and the DNA damage response in cancer
US Srinivas, BWQ Tan, BA Vellayappan… - Redox biology, 2019 - Elsevier
Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-
containing molecules that can induce DNA damage and affect the DNA damage response …
containing molecules that can induce DNA damage and affect the DNA damage response …
Regulatory R-loops as facilitators of gene expression and genome stability
C Niehrs, B Luke - Nature reviews Molecular cell biology, 2020 - nature.com
R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …
during transcription. R-loop misregulation is associated with DNA damage, transcription …
R-loops as cellular regulators and genomic threats
During transcription, the nascent RNA strand can base pair with its template DNA, displacing
the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are …
the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are …
METTL3 and N6-methyladenosine promote homologous recombination-mediated repair of DSBs by modulating DNA-RNA hybrid accumulation
C Zhang, L Chen, D Peng, A Jiang, Y He, Y Zeng… - Molecular cell, 2020 - cell.com
Double-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired,
may lead to genome instability or cell death. Here, we report that, in response to DSBs, the …
may lead to genome instability or cell death. Here, we report that, in response to DSBs, the …
TERRA and RAD51AP1 promote alternative lengthening of telomeres through an R-to D-loop switch
Alternative lengthening of telomeres (ALT), a telomerase-independent process maintaining
telomeres, is mediated by break-induced replication (BIR). RAD52 promotes ALT by …
telomeres, is mediated by break-induced replication (BIR). RAD52 promotes ALT by …
FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation
RNA modifications regulate a variety of cellular processes including DNA repair. The RNA
methyltransferase TRDMT1 generates methyl-5-cytosine (m5C) on messenger RNA (mRNA) …
methyltransferase TRDMT1 generates methyl-5-cytosine (m5C) on messenger RNA (mRNA) …
The DNA damage response to transcription stress
The spatiotemporal control of RNA polymerase II (Pol II)-mediated gene transcription is
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …