Amyotrophic lateral sclerosis (ALS) is a fatal, multigenic, multifactorial, and non-cell
autonomous neurodegenerative disease characterized by upper and lower motor neuron …

RNA-binding proteins (RBPs) are essential factors required for the physiological function of
neurons, muscle, and other tissue types. In kee** with this, a growing body of genetic …

Abstract A missense mutation, S85C, in the MATR3 gene is a genetic cause for amyotrophic
lateral sclerosis (ALS). It is unclear how the S85C mutation affects MATR3 function and …

Summary Matrin-3 (MATR3) is a DNA-and RNA-binding protein implicated in amyotrophic
lateral sclerosis (ALS), frontotemporal dementia (FTD), and distal myopathy. Here, we report …

Matrin‐3 (MATR3) is an RNA‐binding protein implicated in neurodegenerative and
neurodevelopmental diseases. However, little is known regarding the role of MATR3 in …

RNA-binding protein (RBP) dysfunction is a fundamental hallmark of amyotrophic lateral
sclerosis (ALS) and related neuromuscular disorders. Abnormal neuronal excitability is also …

The dysfunction of many RNA-binding proteins (RBPs) that are heavily disordered, including
TDP-43 and FUS, are implicated in amyotrophic lateral sclerosis and frontotemporal …

Matrin-3 (MATR3) was initially discovered as a component of the nuclear matrix about thirty
years ago. Since then, accumulating studies have provided evidence that MATR3 not only …

The F115C mutation in the MATR3 gene has been linked to amyotrophic lateral sclerosis
(ALS). To determine the pathogenicity of the F115C mutation and the mechanism by which …

MATR3 is an RNA-binding protein implicated in neurodegenerative and
neurodevelopmental diseases. However, little is known regarding the role of MATR3 in …