DNA topoisomerases: structure, function, and mechanism
JJ Champoux - Annual review of biochemistry, 2001 - annualreviews.org
▪ Abstract DNA topoisomerases solve the topological problems associated with DNA
replication, transcription, recombination, and chromatin remodeling by introducing …
replication, transcription, recombination, and chromatin remodeling by introducing …
All tangled up: how cells direct, manage and exploit topoisomerase function
Topoisomerases are complex molecular machines that modulate DNA topology to maintain
chromosome superstructure and integrity. Although capable of stand-alone activity in vitro …
chromosome superstructure and integrity. Although capable of stand-alone activity in vitro …
DNA topoisomerases: Advances in understanding of cellular roles and multi‐protein complexes via structure‐function analysis
DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and
indispensable for cellular survival due to the numerous roles they play during DNA …
indispensable for cellular survival due to the numerous roles they play during DNA …
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology
AJ Schoeffler, JM Berger - Quarterly reviews of biophysics, 2008 - cambridge.org
DNA topoisomerases are a diverse set of essential enzymes responsible for maintaining
chromosomes in an appropriate topological state. Although they vary considerably in …
chromosomes in an appropriate topological state. Although they vary considerably in …
Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases
KD Corbett, JM Berger - Annu. Rev. Biophys. Biomol. Struct., 2004 - annualreviews.org
▪ Abstract Topoisomerases are enzymes that use DNA strand scission, manipulation, and
rejoining activities to directly modulate DNA topology. These actions provide a powerful …
rejoining activities to directly modulate DNA topology. These actions provide a powerful …
Archaea and the prokaryote-to-eukaryote transition
Since the late 1970s, determining the phylogenetic relationships among the contemporary
domains of life, the Archaea (archaebacteria), Bacteria (eubacteria), and Eucarya …
domains of life, the Archaea (archaebacteria), Bacteria (eubacteria), and Eucarya …
DNA topoisomerases
DNA topoisomerases are enzymes that control the topology of DNA in all cells. There are
two types, I and II, classified according to whether they make transient single-or double …
two types, I and II, classified according to whether they make transient single-or double …
Origin and evolution of DNA topoisomerases
The DNA topoisomerases are essential for DNA replication, transcription, recombination, as
well as for chromosome compaction and segregation. They may have appeared early during …
well as for chromosome compaction and segregation. They may have appeared early during …
DNA topoisomerases as molecular targets for anticancer drugs
K Buzun, A Bielawska, K Bielawski… - Journal of Enzyme …, 2020 - Taylor & Francis
The significant role of topoisomerases in the control of DNA chain topology has been
confirmed in numerous research conducted worldwide. The prevalence of these enzymes …
confirmed in numerous research conducted worldwide. The prevalence of these enzymes …
Type i DNA topoisomerases
DNA topoisomerases constitute a large family of enzymes that are essential for all domains
of life. Although they share general reaction chemistry and the capacity to govern DNA …
of life. Although they share general reaction chemistry and the capacity to govern DNA …