Transition-metal-catalyzed, coordination-assisted C (sp3)–H functionalization has
revolutionized synthetic planning over the past few decades as the use of these directing …

In 2001, our curiosity to understand the stereochemistry of C− H metalation with Pd
prompted our first studies in Pd (II)‐catalyzed asymmetric C− H activation (RSC Research …

The selective and efficient C–H methylation of sp2 and sp3 carbon centres has become a
powerful transformation in the synthetic toolbox. Due to the potential for profound changes to …

This Review summarizes the advancements in Pd-catalyzed C (sp3)–H activation via
various redox manifolds, including Pd (0)/Pd (II), Pd (II)/Pd (IV), and Pd (II)/Pd (0). While few …

The functionalization of C (sp3)− H bonds streamlines chemical synthesis by allowing the
use of simple molecules and providing novel synthetic disconnections. Intensive recent …

The functionalization of carbon–hydrogen (C–H) bonds is one of the most attractive
strategies for molecular construction in organic chemistry. The hydrogen atom is considered …

Transition metal-catalyzed direct functionalization of C–H bonds is one of the key emerging
strategies that is currently attracting tremendous attention with the aim to provide alternative …

The construction of carbon–carbon bonds is a central tenet of modern synthetic chemistry.
Metal-catalyzed C–H functionalization can serve as a particularly powerful tool for achieving …

Achieving site selectivity in C–H functionalization reactions is a significant challenge,
especially when the target C–H bond is distant from existing functional groups …

Conspectus Enolate alkylation and conjugate addition into an α, β-unsaturated system have
served as long-standing strategic disconnections for the installation of α-or β-substituents on …