[HTML][HTML] Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review

M van Elk, DB Yaden - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
This paper provides a critical review of several possible mechanisms at different levels of
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …

Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders

FX Vollenweider, KH Preller - Nature Reviews Neuroscience, 2020 - nature.com
Renewed interest in the use of psychedelics in the treatment of psychiatric disorders
warrants a better understanding of the neurobiological mechanisms underlying the effects of …

The therapeutic potential of psilocybin

H Lowe, N Toyang, B Steele, H Valentine, J Grant, A Ali… - Molecules, 2021 - mdpi.com
The psychedelic effects of some plants and fungi have been known and deliberately
exploited by humans for thousands of years. Fungi, particularly mushrooms, are the principal …

A neurophenomenological approach to non-ordinary states of consciousness: hypnosis, meditation, and psychedelics

C Timmermann, PR Bauer, O Gosseries… - Trends in cognitive …, 2023 - cell.com
No contemporary unifying framework has been provided for the study of non-ordinary states
of consciousness (NSCs) despite increased interest in hypnosis, meditation, and …

History repeating: guidelines to address common problems in psychedelic science

M van Elk, EI Fried - Therapeutic Advances in …, 2023 - journals.sagepub.com
Research in the last decade has expressed considerable optimism about the clinical
potential of psychedelics for the treatment of mental disorders. This optimism is reflected in …

Preparing for the bursting of the psychedelic hype bubble

DB Yaden, JB Potash, RR Griffiths - JAMA psychiatry, 2022 - jamanetwork.com
Psychedelic research currently appears to be trapped in a hype bubble driven largely by
media and industry interests. We believe that it would benefit the field of psychedelic …

Predicting reactions to psychedelic drugs: A systematic review of states and traits related to acute drug effects

JS Aday, AK Davis, CM Mitzkovitz… - ACS Pharmacology & …, 2021 - ACS Publications
Psychedelic drugs are increasingly being incorporated into therapeutic contexts for the
purposes of promoting mental health. However, they can also induce adverse reactions in …

Naturalistic psilocybin use is associated with persisting improvements in mental health and wellbeing: results from a prospective, longitudinal survey

SM Nayak, H Jackson, ND Sepeda, DS Mathai… - Frontiers in …, 2023 - frontiersin.org
Introduction The classic psychedelic psilocybin, found in some mushroom species, has
received renewed interest in clinical research, showing potential mental health benefits in …

Psychological flexibility as a mechanism of change in psilocybin-assisted therapy for major depression: results from an exploratory placebo-controlled trial

J Sloshower, RJ Zeifman, J Guss, R Krause… - Scientific Reports, 2024 - nature.com
Several phase II studies have demonstrated that psilocybin-assisted therapy shows
therapeutic potential across a spectrum of neuropsychiatric conditions, including major …

A single psilocybin dose is associated with long-term increased mindfulness, preceded by a proportional change in neocortical 5-HT2A receptor binding

MK Madsen, PMD Fisher, DS Stenbæk… - European …, 2020 - Elsevier
A single dose of the serotonin 2A receptor (5-HT2AR) agonist psilocybin can have long-
lasting beneficial effects on mood, personality, and potentially on mindfulness, but …