Pathophysiology associated with traumatic brain injury: current treatments and potential novel therapeutics

ML Pearn, IR Niesman, J Egawa, A Sawada… - Cellular and molecular …, 2017 - Springer
Traumatic brain injury (TBI) is one of the leading causes of death of young people in the
developed world. In the United States alone, 1.7 million traumatic events occur annually …

Use the force: membrane tension as an organizer of cell shape and motility

A Diz-Muñoz, DA Fletcher, OD Weiner - Trends in cell biology, 2013 - cell.com
Many cell phenomena that involve shape changes are affected by the intrinsic deformability
of the plasma membrane (PM). Far from being a passive participant, the PM is now known to …

BAR domain proteins—a linkage between cellular membranes, signaling pathways, and the actin cytoskeleton

PJ Carman, R Dominguez - Biophysical reviews, 2018 - Springer
Actin filament assembly typically occurs in association with cellular membranes. A large
number of proteins sit at the interface between actin networks and membranes, playing …

Caveolae mechanotransduction at the interface between cytoskeleton and extracellular matrix

L Sotodosos-Alonso, M Pulgarín-Alfaro, MA Del Pozo - Cells, 2023 - mdpi.com
The plasma membrane (PM) is subjected to multiple mechanical forces, and it must adapt
and respond to them. PM invaginations named caveolae, with a specific protein and lipid …

PACSIN proteins in vivo: Roles in development and physiology

V Dumont, S Lehtonen - Acta Physiologica, 2022 - Wiley Online Library
Protein kinase C and casein kinase substrate in neurons (PACSINs), or syndapins (synaptic
dynamin‐associated proteins), are a family of proteins involved in the regulation of cell …

Recent developments in membrane curvature sensing and induction by proteins

C Has, SL Das - Biochimica et Biophysica Acta (BBA)-General Subjects, 2021 - Elsevier
Background Membrane-bound intracellular organelles have characteristic shapes attributed
to different local membrane curvatures, and these attributes are conserved across species …

MICAL-family proteins: Complex regulators of the actin cytoskeleton

SSP Giridharan, S Caplan - Antioxidants & redox signaling, 2014 - liebertpub.com
Significance: The molecules interacting with CasL (MICAL) family members participate in a
multitude of activities, including axonal growth cone repulsion, membrane trafficking …

Intrinsically disordered proteins and membranes: a marriage of convenience for cell signalling?

J Cornish, SG Chamberlain, D Owen… - Biochemical Society …, 2020 - portlandpress.com
The structure-function paradigm has guided investigations into the molecules involved in
cellular signalling for decades. The peripheries of this paradigm, however, start to unravel …

Membrane sha** by the Bin/amphiphysin/Rvs (BAR) domain protein superfamily

Y Rao, V Haucke - Cellular and Molecular Life Sciences, 2011 - Springer
BAR domain superfamily proteins have emerged as central regulators of dynamic
membrane remodeling, thereby playing important roles in a wide variety of cellular …

Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis

SSP Giridharan, B Cai, N Vitale… - Molecular biology of …, 2013 - molbiolcell.org
Endocytic transport necessitates the generation of membrane tubules and their subsequent
fission to transport vesicles for sorting of cargo molecules. The endocytic recycling …