Percutaneous Coronary Intervention (PCI) is currently the most conventional and effective
method for clinically treating cardiovascular diseases such as atherosclerosis. Stent …

Restenosis, defined as the re-narrowing of an arterial lumen after revascularization,
represents an increasingly important issue in clinical practice. Indeed, as the number of stent …

Coronary stent designs have undergone significant transformations in geometry, materials,
and drug elution coatings, contributing to the continuous improvement of stenting success …

The widespread incidence of cardiovascular diseases and associated mortality and
morbidity, along with the advent of powerful computational resources, have fostered an …

Hemodynamic factors, induced by pulsatile blood flow, play a crucial role in vascular health
and diseases, such as the initiation and progression of atherosclerosis. Computational fluid …

In this study, we propose a novel computational framework for designing innovative self-
expandable femoral stents. First, a two-dimensional stent unit cell is designed by inverse …

In-stent restenosis (ISR) is a maladaptive inflammatory-driven response of femoral arteries
to percutaneous transluminal angioplasty and stent deployment, leading to lumen re …

Multiscale agent-based modeling frameworks have recently emerged as promising
mechanobiological models to capture the interplay between biomechanical forces, cellular …

Since the introduction of percutaneous coronary intervention (PCI) for the treatment of
obstructive coronary artery disease (CAD), patient outcomes have progressively improved …

Abstract Background Superficial femoral arteries (SFAs) treated with self-expanding stents
are widely affected by in-stent restenosis (ISR), especially in case of long lesions and …