The PI3K-AKT-mTOR pathway and prostate cancer: at the crossroads of AR, MAPK, and WNT signaling
BY Shorning, MS Dass, MJ Smalley… - International journal of …, 2020 - mdpi.com
Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …
Dopamine receptors–IUPHAR R eview 13
The variety of physiological functions controlled by dopamine in the brain and periphery is
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …
The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients
J Hallin, LD Engstrom, L Hargis, A Calinisan, R Aranda… - Cancer discovery, 2020 - AACR
Despite decades of research, efforts to directly target KRAS have been challenging.
MRTX849 was identified as a potent, selective, and covalent KRASG12C inhibitor that …
MRTX849 was identified as a potent, selective, and covalent KRASG12C inhibitor that …
Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method
Single-cell analysis reveals aspects of cellular physiology not evident from population-
based studies, particularly in the case of highly multiplexed methods such as mass …
based studies, particularly in the case of highly multiplexed methods such as mass …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
Signaling pathways involved in the regulation of mRNA translation
Translation is a key step in the regulation of gene expression and one of the most energy-
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …
Dominant-activating germline mutations in the gene encoding the PI (3) K catalytic subunit p110δ result in T cell senescence and human immunodeficiency
The p110δ subunit of phosphatidylinositol-3-OH kinase (PI (3) K) is selectively expressed in
leukocytes and is critical for lymphocyte biology. Here we report fourteen patients from …
leukocytes and is critical for lymphocyte biology. Here we report fourteen patients from …
Evolutionarily divergent mTOR remodels translatome for tissue regeneration
O Zhulyn, HD Rosenblatt, L Shokat, S Dai… - Nature, 2023 - nature.com
An outstanding mystery in biology is why some species, such as the axolotl, can regenerate
tissues whereas mammals cannot. Here, we demonstrate that rapid activation of protein …
tissues whereas mammals cannot. Here, we demonstrate that rapid activation of protein …
Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue
Limitations on the number of unique protein and DNA molecules that can be characterized
microscopically in a single tissue specimen impede advances in understanding the …
microscopically in a single tissue specimen impede advances in understanding the …
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
The Ras-extracellular signal-regulated kinase (Ras-ERK) and phosphatidylinositol 3-kinase-
mammalian target of rapamycin (PI3K-mTOR) signaling pathways are the chief mechanisms …
mammalian target of rapamycin (PI3K-mTOR) signaling pathways are the chief mechanisms …