Tumor angiogenesis: causes, consequences, challenges and opportunities

R Lugano, M Ramachandran, A Dimberg - Cellular and Molecular Life …, 2020 - Springer
Tumor vascularization occurs through several distinct biological processes, which not only
vary between tumor type and anatomic location, but also occur simultaneously within the …

Role of CD93 in Health and Disease

G Tossetta, F Piani, C Borghi, D Marzioni - Cells, 2023 - mdpi.com
CD93 (also known as complement protein 1 q subcomponent receptor C1qR1 or C1qRp), is
a transmembrane glycoprotein encoded by a gene located on 20p11. 21 and composed of …

Single-cell RNA sequencing of lymph node stromal cells reveals niche-associated heterogeneity

LB Rodda, E Lu, ML Bennett, CL Sokol, X Wang… - Immunity, 2018 - cell.com
Stromal cells (SCs) establish the compartmentalization of lymphoid tissues critical to the
immune response. However, the full diversity of lymph node (LN) SCs remains undefined …

Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy

Y Sun, W Chen, RJ Torphy, S Yao, G Zhu… - Science translational …, 2021 - science.org
The immature and dysfunctional vascular network within solid tumors poses a substantial
obstacle to immunotherapy because it creates a hypoxic tumor microenvironment that …

A review of anti-angiogenic targets for monoclonal antibody cancer therapy

DH Kong, MR Kim, JH Jang, HJ Na, S Lee - International journal of …, 2017 - mdpi.com
Tumor angiogenesis is a key event that governs tumor progression and metastasis. It is
controlled by the complicated and coordinated actions of pro-angiogenic factors and their …

CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis

R Lugano, K Vemuri, D Yu, M Bergqvist… - The Journal of …, 2018 - Am Soc Clin Investig
Tumor angiogenesis occurs through regulation of genes that orchestrate endothelial
sprouting and vessel maturation, including deposition of a vessel-associated extracellular …

The dual role of mesenchymal stem cells in cancer pathophysiology: pro-tumorigenic effects versus therapeutic potential

Y Slama, F Ah-Pine, M Khettab, A Arcambal… - International Journal of …, 2023 - mdpi.com
Mesenchymal stem/stromal cells (MSCs) are multipotent cells involved in numerous
physiological events, including organogenesis, the maintenance of tissue homeostasis …

C‐type lectin domain group 14 proteins in vascular biology, cancer and inflammation

KA Khan, JL McMurray, F Mohammed… - The FEBS …, 2019 - Wiley Online Library
The C‐type lectin domain (CTLD) group 14 family of transmembrane glycoproteins consist of
thrombomodulin, CD 93, CLEC 14A and CD 248 (endosialin or tumour endothelial marker …

CD248 regulates Wnt signaling in pericytes to promote angiogenesis and tumor growth in lung cancer

CL Hong, IS Yu, CH Pai, JS Chen, MS Hsieh, HL Wu… - Cancer Research, 2022 - AACR
The tumor microenvironment plays a central role in cancer initiation and progression.
CD248 is expressed in tumor-associated stromal cells, particularly fibroblasts and pericytes …

Dual‐Functional Nanodroplet for Tumor Vasculature Ultrasound Imaging and Tumor Immunosuppressive Microenvironment Remodeling

Y Liang, S Zhang, D Wang, P Ji… - Advanced …, 2024 - Wiley Online Library
Accurately evaluating tumor neoangiogenesis and conducting precise interventions toward
an immune‐favorable microenvironment are of significant clinical importance. In this study, a …