Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization

Y Wu, K Chen, J Wang, M Chen, W Dai… - Journal of the American …, 2024 - ACS Publications
Polypeptides have the same or similar backbone structures as proteins and peptides,
rendering them as suitable and important biomaterials. Amino acid N-carboxyanhydrides …

Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids

AR Mazo, S Allison-Logan, F Karimi… - Chemical society …, 2020 - pubs.rsc.org
Polypeptides have attracted considerable attention in recent decades due to their inherent
biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with …

A moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides

ZY Tian, Z Zhang, S Wang, H Lu - Nature Communications, 2021 - nature.com
A great hurdle in the production of synthetic polypeptides lies in the access of N-
carboxyanhydrides (NCA) monomers, which requires dry solvents, Schlenk line/gloveboxe …

Polysarcosine-containing copolymers: Synthesis, characterization, self-assembly, and applications

A Birke, J Ling, M Barz - Progress in Polymer Science, 2018 - Elsevier
Although the first polysarcosine (pSar) synthesis by Wesseley et al. was reported almost a
century ago, it was only recently that pSar gained broader attention and is considered a …

Recent Advances and Future Perspectives of Synthetic Polypeptides from N-Carboxyanhydrides

Z Song, Z Tan, J Cheng - Macromolecules, 2019 - ACS Publications
Synthetic polypeptides, the analogues of natural proteins, are important biomaterials that
have found broad biomedical applications. Ring-opening polymerization of N …

Water‐insensitive synthesis of poly‐β‐peptides with defined architecture

M Zhou, X **ao, Z Cong, Y Wu, W Zhang… - Angewandte Chemie …, 2020 - Wiley Online Library
Biocompatible and proteolysis‐resistant poly‐β‐peptides have broad applications and are
dominantly synthesized via the harsh and water‐sensitive ring‐opening polymerization of β …

Synthetic peptide branched polymers for antibacterial and biomedical applications

S Shabani, S Hadjigol, W Li, Z Si, D Pranantyo… - Nature Reviews …, 2024 - nature.com
Antimicrobial resistance is a major threat to human health, and this 'invisible pandemic'is a
looming public health crisis. Accordingly, both broad-spectrum and selective antimicrobial …

Biodegradable polysarcosine with inserted alanine residues: Synthesis and enzymolysis

P Zhou, T Shen, W Chen, J Sun, J Ling - Biomacromolecules, 2022 - ACS Publications
Polysarcosine (PSar), a water-soluble polypeptoid, is gifted with biodegradability via the
random ring-opening copolymerization of sarcosine-and alanine-N-thiocarboxyanhydrides …

Biological applications of water-soluble polypeptides with ordered secondary structures

C Ge, H Ye, F Wu, J Zhu, Z Song, Y Liu… - Journal of Materials …, 2020 - pubs.rsc.org
Water-soluble polypeptides are a class of synthetic polymers with peptide bond frameworks
imitating natural proteins and have broad prospects in biological applications. The …

Oxidation-sensitive polymersomes based on amphiphilic diblock copolypeptoids

Y Deng, H Chen, X Tao, F Cao, S Trépout… - …, 2019 - ACS Publications
Stimuli-responsive polymersomes formed by amphiphilic block copolymers have attracted
substantial attention as smart and robust containers for drug delivery and …