Adaptive Cost-Benefit Control Fueled by Striatal Dopamine
MJ Frank - Annual Review of Neuroscience, 2025 - annualreviews.org
The twenty-first century has brought forth a deluge of theories and data shedding light on the
neural mechanisms of motivated behavior. Much of this progress has focused on …
neural mechanisms of motivated behavior. Much of this progress has focused on …
A feature-specific prediction error model explains dopaminergic heterogeneity
The hypothesis that midbrain dopamine (DA) neurons broadcast a reward prediction error
(RPE) is among the great successes of computational neuroscience. However, recent …
(RPE) is among the great successes of computational neuroscience. However, recent …
A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors
Striatal acetylcholine and dopamine critically regulate movement, motivation, and reward-
related learning. Pauses in cholinergic interneuron (CIN) firing are thought to coincide with …
related learning. Pauses in cholinergic interneuron (CIN) firing are thought to coincide with …
Neuronal encoding of behaviors and instrumental learning in the dorsal striatum
C Varin, A de Kerchove d'Exaerde - Trends in neurosciences, 2024 - cell.com
The dorsal striatum is instrumental in regulating motor control and goal-directed behaviors.
The classical description of the two output pathways of the dorsal striatum highlights their …
The classical description of the two output pathways of the dorsal striatum highlights their …
Striosomes control dopamine via dual pathways paralleling canonical basal ganglia circuits
Balanced activity of canonical direct D1 and indirect D2 basal ganglia pathways is
considered a core requirement for normal movement, and their imbalance is an etiologic …
considered a core requirement for normal movement, and their imbalance is an etiologic …
Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning
Environmental cues, through Pavlovian learning, become conditioned stimuli that invigorate
and guide animals toward rewards. Dopamine (DA) neurons in the ventral tegmental area …
and guide animals toward rewards. Dopamine (DA) neurons in the ventral tegmental area …
Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors
Dopamine (DA) release in striatal circuits, including the nucleus accumbens medial shell
(mNAcSh), tracks separable features of reward like motivation and reinforcement. However …
(mNAcSh), tracks separable features of reward like motivation and reinforcement. However …
Pre-existing visual responses in a projection-defined dopamine population explain individual learning trajectories
A key challenge of learning a new task is that the environment is high dimensional—there
are many different sensory features and possible actions, with typically only a small reward …
are many different sensory features and possible actions, with typically only a small reward …
Few-shot learning: temporal scaling in behavioral and dopaminergic learning
How do we learn associations in the world (eg, between cues and rewards)? Cue-reward
associative learning is controlled in the brain by mesolimbic dopamine–. It is widely believed …
associative learning is controlled in the brain by mesolimbic dopamine–. It is widely believed …
“But why?” Dopamine and causal learning
VMK Namboodiri - Current Opinion in Behavioral Sciences, 2024 - Elsevier
Highlights•Identifying algorithmic functions of mesolimbic dopamine is crucial.•Temporal
difference reward prediction error inconsistent with recent data.•Alternative model with …
difference reward prediction error inconsistent with recent data.•Alternative model with …