The majority of cancer-related deaths in the United States and worldwide are attributed to
lung cancer. There are more than 90 million smokers in the United States who represent a …

Metastatic prostate cancer is one of the leading causes of male cancer deaths in the western
world. Obesity significantly increases the risk of metastatic disease and is associated with a …

There is increasing interest in periprostatic fat and its influence on prostate cancer
aggressiveness. In vitro data suggest that adipose stromal/stem cells (ASC s) can increase …

Abstract Objectives Copy number alterations (CNAs) are frequently found in malignant
tissues. Different approaches have been used for CNA detection. However, it is not easy to …

Background: To assess the predictive value of visceral adipose tissue (VAT) and adipose
tissue density after both radical prostatectomy (RP) and adjuvant or salvage external beam …

The reproducibility of scientific processes is one of the paramount problems of
bioinformatics, an engineering problem that must be addressed to perform good research …

Motivation CNValidator assesses the quality of somatic copy-number calls based on
coherency of haplotypes across multiple samples from the same individual. It is applicable to …

The probability of gene manifestation in cancer from a set of heterogeneous experimental
data with standard deviation are studied for the definition of the Markov chain from which the …

Somatic copy-number (CN) gains and losses and copy-neutral loss of heterozygosity
(CNLOH) frequently occur in tumors and play a major role in the progression of disease by …