Schizophrenia is a complex neuropsychiatric syndrome with a heterogeneous genetic,
neurobiological, and phenotypic profile. Currently, no objective biological measures—that is …

Abstract Background The glutamate (Glu) and gamma aminobutyric acid (GABA)
hypotheses of schizophrenia were proposed in the 1980s. However, current findings on …

Importance Alterations in glutamatergic neurotransmission may be fundamental to the
pathophysiology of schizophrenia, and the glutamatergic system is a target for novel …

This guidance paper from the European Psychiatric Association (EPA) aims to provide
evidence-based recommendations on early intervention in clinical high risk (CHR) states of …

Importance Proton magnetic resonance spectroscopy (1H-MRS) studies indicate that altered
brain glutamatergic function may be associated with the pathophysiology of schizophrenia …

The thalamus is a crucial node for brain physiology and part of functional and structural
pathways relevant for schizophrenia. Relatively few imaging studies on schizophrenia have …

Conventional antipsychotic medication is ineffective in around a third of patients with
schizophrenia, and the nature of the therapeutic response is unpredictable. We investigated …

Elevated dopamine function and alterations in medial temporal lobe (MTL) structure and
function are two of the most robust findings in schizophrenia, but how interactions between …

The introduction of clinical criteria for the operationalization of psychosis high risk provided a
basis for early detection and treatment of vulnerable individuals. However, about two-thirds …

A diet rich in B-group vitamins is essential for optimal body and brain function, and
insufficient amounts of such vitamins have been associated with higher levels of neural …