Deubiquitinating enzymes in cellular signaling and disease regulation
Protein post‐translational modification by ubiquitin represents a complex signaling system
that regulates many cellular events including proteostasis to intercellular communications …
that regulates many cellular events including proteostasis to intercellular communications …
The function and regulation of OTU deubiquitinases
J Du, L Fu, Y Sui, L Zhang - Frontiers of Medicine, 2020 - Springer
Post-translational modification of cellular proteins by ubiquitin regulates numerous cellular
processes, including cell division, immune responses, and apoptosis. Ubiquitin-mediated …
processes, including cell division, immune responses, and apoptosis. Ubiquitin-mediated …
Application of next generation sequencing (NGS) in phage displayed peptide selection to support the identification of arsenic-binding motifs
Next generation sequencing (NGS) in combination with phage surface display (PSD) are
powerful tools in the newly equipped molecular biology toolbox for the identification of …
powerful tools in the newly equipped molecular biology toolbox for the identification of …
The unity of opposites: Strategic interplay between bacterial effectors to regulate cellular homeostasis
S Iyer, C Das - Journal of Biological Chemistry, 2021 - ASBMB
Legionella pneumophila is a facultative intracellular pathogen that uses the Dot/Icm Type IV
secretion system (T4SS) to translocate many effectors into its host and establish a safe …
secretion system (T4SS) to translocate many effectors into its host and establish a safe …
Familial mutations and post-translational modifications of UCH-L1 in Parkinson's disease and neurodegenerative disorders
YT C. Lee, ST D. Hsu - Current Protein and Peptide Science, 2017 - benthamdirect.com
Parkinson's disease (PD) is one of the most common progressive neurodegenerative
disorders in modern society. The disease involves many genetic risk factors as well as a …
disorders in modern society. The disease involves many genetic risk factors as well as a …
K27-linked diubiquitin inhibits UCHL3 via an unusual kinetic trap
Functional analysis of lysine 27-linked ubiquitin chains (K27 Ub) is difficult due to the
inability to make them through enzymatic methods and due to a lack of model tools and …
inability to make them through enzymatic methods and due to a lack of model tools and …
The Two Deubiquitinating Enzymes from Chlamydia trachomatis Have Distinct Ubiquitin Recognition Properties
Chlamydia trachomatis is the cause of several diseases such as sexually transmitted
urogenital disease and ocular trachoma. The pathogen contains a small genome yet, upon …
urogenital disease and ocular trachoma. The pathogen contains a small genome yet, upon …
Altered Protein Dynamics and a More Reactive Catalytic Cysteine in a Neurodegeneration-associated UCHL1 Mutant
A mutant of ubiquitin C-terminal hydrolase L1 (UCHL1) detected in early-onset
neurodegenerative patients, UCHL1 R178Q, showed higher catalytic activity than wild-type …
neurodegenerative patients, UCHL1 R178Q, showed higher catalytic activity than wild-type …
Entropic stabilization of a deubiquitinase provides conformational plasticity and slow unfolding kinetics beneficial for functioning on the proteasome
YTC Lee, CY Chang, SY Chen, YR Pan, MR Ho… - Scientific reports, 2017 - nature.com
Human ubiquitin C-terminal hydrolyase UCH-L5 is a topologically knotted deubiquitinase
that is activated upon binding to the proteasome subunit Rpn13. The length of its intrinsically …
that is activated upon binding to the proteasome subunit Rpn13. The length of its intrinsically …
ADAR promotes USP38 auto-deubiquitylation and stabilization in an RNA editing–independent manner in esophageal squamous cell carcinoma
Q Hu, Y Chen, Q Zhou, S Deng, W Hou, Y Yi, C Li… - Journal of Biological …, 2024 - jbc.org
Esophageal cancer is mainly divided into esophageal adenocarcinoma and esophageal
squamous cell carcinoma (ESCC). China is one of the high-incidence areas of esophageal …
squamous cell carcinoma (ESCC). China is one of the high-incidence areas of esophageal …